Results 31 to 40 of about 921,908 (302)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Percent of health workers in Jigawa carrying out IMCI assessment.

open access: yes, 2012
Percent of health workers in Jigawa carrying out IMCI assessment.
Joseph J. Valadez (132278)   +6 more
core   +1 more source

Public Hearings as a Political and Legal Instrument of the Direct Democracy and Social Resource of the Local Government Activity Legitimacy

open access: yesÈkonomika, Pedagogika i Pravo, 2015
In the present article author considers theoretical legal questions of carrying out public hearings in municipalities, municipal acts and practice of carrying out public hearings are analyzed, problems of legal regulation of public hearings in ...
Natalia N. Kuleshona
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Software for Expert Information Processing During Carrying out the Examinations [PDF]

open access: yes, 2007
The system of the automated carrying out of examinations is described. Opportunities of system, its architecture and structure of communications between functional subsystems are resulted. Features of the subsystems making system are described.
Gnatienko, Grigory
core  

RIGHT TO LAND AT THE CROSSROADS: The povo de santo and the fight for dignity

open access: yesSur: International Journal on Human Rights, 2019
This text is a reflection on the struggle of the people of the African-derived religions in Brazil, for the right to land. The different notions of land in the dispute of civilisations and the need to include the struggle for the right to land in the ...
Humberto Manoel de Santana Jr.
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Carrying out of internal audit at the enterprise: process aspect

open access: yes, 2011
Визначено етапи проведення внутрішнього аудиту з врахуванням процесного підходу до управління підприємством. Запропоновано методичне забезпечення для ефективної реалізації зазначених складових етапів здійснення внутрішнього аудиту. Stages of carrying out
Захарченко, В. Ю.   +5 more
core   +2 more sources

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