Results 91 to 100 of about 361,692 (241)

Pin-tract infection is an important factor associated with pin loosening during external fixation: a prospective analysis of 47 consecutive patients

Frontiers in Cellular and Infection Microbiology
BackgroundThe occurrence of pin loosening represents a common issue in the context of external fixation methodologies; nevertheless, a comprehensive investigation into the multifaceted causes of pin loosening, incorporating a multivariate analysis among ...
Yong-yi Huang, Yong-yi Huang, Yong-yi Huang, Mou-zhang Huang, Ping Zhang, Ping Zhang, Chen-sheng Song, Yu Yao, Yu-sheng Yang, Yu-sheng Yang, Liang-jie Tian, Qing-rong Lin, Qing-rong Lin, Qing-rong Lin, Ru-hao Han, Ru-hao Han, Hong-wei Xi, Bo-wei Wang, Bo-wei Wang, Nan Jiang, Nan Jiang, Yan-jun Hu, Yan-jun Hu   +22 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis

Nature Communications
Staphylococcus aureus (S. aureus)-induced osteomyelitis remains challenging in clinical practice, wherein macrophages with impaired bactericidal function serve as reservoirs for intracellular bacterial survival, contributing to persistent and relapsing ...
Xin Guan, Bingsheng Yang, Bowen Bai, Naiqian Cui, Muqi Wang, Jianwen Su, Xiaohu Wu, Chenghua Zhang, Hui Dai, Peng Zhao, Bin Yu, Bowei Wang   +11 more
doaj   +1 more source

Is cartilage sGAG content related to early changes in cartilage disease? Implications for interpretation of dGEMRIC.

, 2012
SummaryObjectiveThis study investigates sulphated glycosaminoglycans (sGAG) content changes in early osteoarthritis (OA), and whether contrast-enhanced magnetic resonance imaging (MRI) of cartilage in vitro may identify early event of OA pathology ...
Heinegård, Dick, Stubendorff, Johann, Dahlberg, Leif, Lammentausta, Eveliina, Struglics, André, Lindberg, Lisbeth, Lindberg, Lisbeth,, Heinegård, Dick,, Dahlberg, Leif,, Lund University., Struglics, André,   +10 more
core   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

The association between chondral lesions and patient-reported outcomes after meniscectomy: Data from the Osteoarthritis Initiative

Journal of Cartilage & Joint Preservation
Introduction: Evidence and guidelines around the treatment of meniscal tears in patients with knee osteoarthritis (OA) are conflicting, and the impact of chondral damage on surgical outcomes is unclear.
Ali Guermazi, Jamie E. Collins, Jared P. Sachs, Yusuf N. Mufti, Brian J. Cole   +4 more
doaj   +1 more source

Carboxymethyl chitosan–zinc coating for prevention of pin tract infection: An animal model

Journal of Orthopaedic Surgery, 2018
Background: Pin tract infection is a common problem in orthopedic and traumatology surgery. The aim of this study was to investigate the efficacy of an implant coated with carboxymethyl chitosan–zinc (CMC-Zn 2+ ) in prevention of pin tract infection ...
Vidmi Taolam Martin, Lei Wang, Rong Zeng, DeQiang You, XianRong Zhang, Welera Haissou Elodie, Bin Yu   +6 more
doaj   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source