Results 131 to 140 of about 707,817 (385)

Deep Learning Approach for Evaluating Knee MR Images: Achieving High Diagnostic Performance for Cartilage Lesion Detection.

Radiology, 2018
Purpose To determine the feasibility of using a deep learning approach to detect cartilage lesions (including cartilage softening, fibrillation, fissuring, focal defects, diffuse thinning due to cartilage degeneration, and acute cartilage injury) within ...
Fang Liu, Zhaoye Zhou, A. Samsonov, D. Blankenbaker, Will G. Larison, Andrew Kanarek, Kevin Lian, S. Kambhampati, Richard Kijowski   +8 more
semanticscholar   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Exosomes in cartilage microenvironment regulation and cartilage repair

Frontiers in Cell and Developmental Biology
Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens.
Han Longfei, Hou Wenyuan, Fang Weihua, Peng Peng, Lu Sun, Lin Kun, He Mincong, He Mincong, Yang Fan, Yang Fan, He Wei, He Wei, Wei Qiushi, Wei Qiushi, Wei Qiushi   +14 more
openaire   +3 more sources

Revealing the Auxetic Behavior of Biomimetic Multimaterial and Region‐Specific Nanofibrous Fascicle‐Inspired Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration

Advanced Functional Materials, EarlyView.
Enthesis injuries are a worldwide healthcare problem. Biomimetic electrospun enthesis fascicle‐inspired scaffolds, with and without nano‐mineralization are developed. Human Mesenchymal Stromal cells (hMSCs) express the most balanced enthesis markers on the non‐mineralized scaffolds.
Alberto Sensini, Francesca Giacomini, Olga Stamati, Bratislav Lukic, Julie Villanova, Henry Proudhon, Maryse Gille, Zeinab Tahmasebi Birgani, Roman Truckenmüller, Gianluca Tozzi, Martijn van Griensven, Lorenzo Moroni   +11 more
wiley   +1 more source

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

International Journal of Molecular Sciences, 2018
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal.
E. V. Medvedeva, E. Grebenik, S. Gornostaeva, Vladimir I. Telpuhov, A. Lychagin, P. Timashev, A. Chagin   +6 more
semanticscholar   +1 more source

Ionic Control of Microstructure and Lubrication in Charged, Physically Cross‐Linked Hydrogels

Advanced Functional Materials, EarlyView.
Here, charged, physically cross‐linked poly(methacrylamide‐co‐methacrylic acid) hydrogels stabilized by a short‐range attractive, long‐range repulsive potential is investigated. This work uncovers how salt addition alters not only swelling, but also the microstructure and dynamics, near‐surface stiffness and charge, and ultimately, its lubricity. Salts
Alexander Deptula, Rosa M. Espinosa‐Marzal   +1 more
wiley   +1 more source

The Contact Between the Articular Cartilage and the Medullary Cavities of the Bone [PDF]

, 1950
D. E. Holmdahl, Bo E. Ingelmark
openalex   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, EarlyView.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

Mechanical confinement regulates cartilage matrix formation by chondrocytes

Nature Materials, 2017
Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.
Hong-pyo Lee, Luo Gu, D. Mooney, M. Levenston, Ovijit Chaudhuri   +4 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source