Results 111 to 120 of about 91,123 (253)

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch   +7 more
wiley   +1 more source

Black humour processing in the light of the conceptual integration theory and the benign violation theory

open access: yesExELL (Explorations in English Language and Linguistics)
The aim of the paper is to reveal that humour processing is an exertion which requires both, mental and emotional capacities. To prove the point, two theories for humour processing were employed: the conceptual integration theory and the benign ...
Kemal Avdagić
doaj  

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

open access: yesBMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie   +12 more
wiley   +1 more source

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez   +15 more
wiley   +1 more source

Ultra‐Wideline 2D Correlations Among Low‐γ Species in Solid‐State NMR via the Progressive Saturation of a Common Proton Reservoir

open access: yesChemistry – A European Journal, EarlyView.
This study introduces PROSPECT, a 2D solid‐state NMR method that correlates MHz‐wide, low‐γ anisotropic powder patterns. PROSPECT operates by progressively depleting a shared 1H dipolar‐order reservoir via two independently stepped cross‐polarizing offsets, yielding homonuclear and heteronuclear correlations without requiring direct transfers or even ...
Rihards Aleksis, Lucio Frydman
wiley   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

open access: yesChemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova   +11 more
wiley   +1 more source

Exploring Calixarene‐Based Pseudorotaxane Architectures: Threading Ammonium Axles With an Exo‐Rim π‐Functionalized Calix[6]Arene Macrocycle

open access: yesChemistry – A European Journal, EarlyView.
This research presents a novel 1,4‐π‐functionalized calix[6]arene with enhanced interactions with dialkylammonium axles. We investigate threading behavior in CDCl3, highlighting how exo‐rim π‐functionalization affects binding affinity and stereoselectivity.
Veronica Iuliano   +7 more
wiley   +1 more source

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