Results 21 to 30 of about 19,471 (205)

How Carvedilol activates β2-adrenoceptors [PDF]

, 2022
Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear.
Shannon O’Brien, Nadine Dobberstein, Zeiner, Julian, Mirjam Zimmermann, Edda Sofie Fabienne Matthees, Daniela Malan, Maria Waldhoer, Hoffmann, Carsten, Stefania Monteleone, Viacheslav Nikolaev, Benkel, Tobias, Bravo, Sergi, Malan, Daniela, Kolb, Peter, Carsten Hoffmann, Calebiro, Davide, Chevigné, Andy, Elke Miess-Tanneberg, Lanoiselée, Yann, Dobberstein, Nadine, Kostenis, Evi, Tobias Benkel, Jak Grimes, Waldhoer, Maria, Zsombor Koszegi, O’Brien, Shannon; id_orcid, Jesus Gomeza, Koszegi, Zsombor, Szpakowska, Martyna, Monteleone, Stefania, Inoue, Asuka, Nikoleta Pavlaki, Andy Chevigné, Nicole Merten, Nikolaev, Viacheslav, Schulz, Stefan, Martyna Szpakowska, Merten, Nicole, Stefan Schulz, O’Brien, Shannon, Philipp Sasse, Lim, Victor Jun Yu, Davide Calebiro, Julia Drube, Simon, Katharina, Grimes, Jak, Drube, Julia, Victor Jun Yu Lim, Koszegi, Zsombor; id_orcid, Peter Kolb, Gomeza, Jesus, Matthees, Edda Sofie Fabienne, Pavlaki, Nikoleta, Yann Lanoiselée, Asuka Inoue, Zimmermann, Mirjam, Katharina Simon, Evi Kostenis, Miess-Tanneberg, Elke, Sasse, Philipp, Julian Zeiner, Sergi Bravo   +61 more
core   +1 more source

PHARMACOECONOMIC ANALYSIS OF CARVEDILOL THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC RISK FACTORS (ACCORDING TO THE CAMELLIA STUDY)

Рациональная фармакотерапия в кардиологии, 2016
Aim. To perform cost-effectiveness analysis of 24 weeks antihypertensive therapy based on carvedilol or metoprolol in patients with arterial hypertension (HT) 1-2 degrees and overweight/obesity. To assess effects of carvedilol therapy on 10-year expected
S. Y. Martsevich, N. P. Kutishenko, A. D. Deev, S. A. Shalnova, R. G. Oganov   +4 more
doaj   +1 more source

Solubility enhancement of carvedilol by multicomponent crystal approach using glycine and arginine as coformers [PDF]

Pharmacia, 2023
A Carvedilol is a member of BCS class II, it has a low solubility and bioavailability. This work intends to increase the solubility of carvedilol using a multicomponent crystal method.
Iyan Sopyan, Wuri Ariestika Sari, Sandra Megantara, Taofik Rusdiana   +3 more
doaj   +3 more sources

Assessment of clinical effect and treatment quality of immediate-release carvedilol-IR versus SLOW release carvedilol-SR in Heart Failure patients (SLOW-HF): study protocol for a randomized controlled trial

Trials, 2018
Background Carvedilol is a non-selective, third-generation beta-blocker and is one of the cornerstones for treatment for patients with heart failure and reduced ejection fraction (HFrEF). However, due to its short half-life, immediate-release carvedilol (
Dong-Ju Choi, Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Seok Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-Ju Kim, Soon-Jun Hong, Seok Yeon Kim, Jae-Joong Kim   +14 more
doaj   +1 more source

The Potential Benefits of Using Garlic Oil and Its Active Constituent, Dially Disulphide, in Combination With Carvedilol in Ameliorating Isoprenaline-Induced Cardiac Damage in Rats

Frontiers in Pharmacology, 2021
Garlic oil and its primary component, diallyl disulphide (DADS), were tested in rats with isoprenaline (ISO) induced myocardial infarction for cardioprotective benefits when combined with carvedilol.
Syed Mohammed Basheeruddin Asdaq, Obulesu Challa, Abdulhakeem S. Alamri, Abdulhakeem S. Alamri, Walaa F. Alsanie, Walaa F. Alsanie, Majid Alhomrani, Majid Alhomrani, Mohammed Asad   +8 more
doaj   +1 more source

Development of Carvedilol-Loaded Albumin-Based Nanoparticles with Factorial Design to Optimize In Vitro and In Vivo Performance

Pharmaceutics, 2023
Carvedilol, an anti-hypertensive medication commonly prescribed by healthcare providers, falls under the BCS class II category due to its low-solubility and high-permeability characteristics, resulting in limited dissolution and low absorption when taken
Mohamed S. Attia, Mohamed F. Radwan, Tarek S. Ibrahim, Tarek M. Ibrahim   +3 more
doaj   +1 more source

Differential effects of adrenergic antagonists (Carvedilol vs Metoprolol) on parasympathetic and sympathetic activity: a comparison of clinical results

Heart International, 2014
Background Cardiovascular autonomic neuropathy (CAN) is recognized as a significant health risk, correlating with risk of heart disease, silent myocardial ischemia or sudden cardiac death.
Heather L. Bloom, Aaron I. Vinik, Joe Colombo   +2 more
doaj   +1 more source

Comparative Analysis of Compendial Quality Requirements for Carvedilol Products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Carvedilol is a drug used to treat renovascular hypertension and cardiovascular diseases. A monograph for carvedilol drug substance has been included in the State Pharmacopeia of the Russian Federation (SP RF); however, quality requirements
A. I. Belanova, E. V. Lankina, A. A. Taranova   +2 more
doaj   +1 more source

Carvedilol versus propranolol in the prevention of variceal rebleeding in hepatosplenic schistosomiasis: Efficacy and safety

JGH Open, 2022
Background and Aim Beta blockers combined with endoscopic variceal band ligation (EVL) is the most effective means for the prevention of variceal rebleeding.
Chantelli Iamblaudiot Razafindrazoto, Lova Dany Ella Razafindrabekoto, Domoina Harivonjy Hasina Laingonirina, Raveloson Raveloson, Anjaramalala Sitraka Rasolonjatovo, Andry Lalaina Rinà Rakotozafindrabe, Tovo Harimanana Rabenjanahary, Soloniaina Hélio Razafimahefa, Rado Manitrala Ramanampamonjy   +8 more
doaj   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source