Results 201 to 210 of about 250,431 (264)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

The NRT1.1-NLP7 Nexus: An Integrative Signaling Nexus from Nitrate Sensing to Systemic Adaptation and Structure-Guided Engineering. [PDF]

Plants (Basel)
Chen J, Chen R, Li Q, Zhan Y.
europepmc   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Nicotine biosynthesis is completed by cryptic activating glucosylation. [PDF]

Nat Commun
Schwabe BTW, Angstman IM, Vollheyde K, Ingold Z, Li J, Stankevich KS, Spicer CD, Fascione MA, Grogan G, Geu-Flores F, Lichman BR.   +10 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Eco-Nanozymology: A Catalytic Paradigm Integrating Energy, Environment, and Ecology. [PDF]

Nanomicro Lett
Shang L, Zhang Z, Lin H, Wang Z, Chen D, Zhu Z.   +5 more
europepmc   +1 more source

Cost-Trajectory Framework for Total Episode Expenditure in Complex Wound Reconstruction: The CASCADE (Cost Analysis of Surgical Complications and Downstream Expenditure) Model. [PDF]

Cureus
Klapper AM, Dardano AN, Risin M, Maita K.   +3 more
europepmc   +1 more source

Elongation of spinal cord reactive astrocytes via LRP1/TRK signaling. [PDF]

Signal Transduct Target Ther
Rodriguez-Jimenez FJ, Selles F, Jendelova P, Erceg S.   +3 more
europepmc   +1 more source

Towards a neurophysiological model of kundalini: a theoretical framework informed by preliminary clinical observations. [PDF]

Front Behav Neurosci
Samanta S, Sultania N, Roychoudhury M, Sharma S, Mitra P.   +4 more
europepmc   +1 more source

Synergistic Integration of Enzyme and Microbial Platforms for Sustainable Management of Pharmaceutical Pollutants: Towards a Greener Pharmaceutical Lifecycle. [PDF]

Biology (Basel)
Sun Z, Chen P, Ge X, Zhang W, Liu H.
europepmc   +1 more source