Results 221 to 230 of about 16,069,310 (302)

The Oxidative-Mitochondrial-Inflammatory Axis in Retinitis Pigmentosa: Extracellular mtDNA as Biomarker and Therapeutic Read-Out. [PDF]

Antioxidants (Basel)
Grimaldi R, Franco F, Vingolo EM.
europepmc   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

A Cascade Catalytic Nanoplatform Enabling PTT/CDT Synergistic Antibacterial and Heat-Triggered NO Release for Angiogenesis in Diabetic Wound Healing. [PDF]

Int J Pharm X
Zhao Y, He J, Dai H, Dai A, Wu S, Liu H, Qiao X, Zhou Q, Gu J, Zhao Y, Chen P, Lv C.   +11 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

High-Pressure Modulation of Breathing Kagome Lattice: Cascade of Lifshitz Transitions and Evolution of the Electronic Structure. [PDF]

Adv Sci (Weinh)
Gonçalves-Faria MV, Wenzel M, Chan YT, Iakutkina O, Capitani F, Comboni D, Hanfland M, Wang Q, Lei H, Dressel M, Tsirlin AA, Pashkin A, Winnerl S, Helm M, Uykur E.   +14 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

A tailored CoA ligase-<i>N</i>-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope. [PDF]

Nat Catal
Schaub D, Lessing A, Meyer F, Stockinger P, Estévez-Gay M, Eichenberger M, von Haugwitz G, Gloger A, Scheuermann J, Buller R.   +9 more
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Enhanced Glucose Recovery from Reed Straw (<i>Phragmites australis</i>) via Cascade Microwave-Alkali and Ultrasound-H₂O₂ Pretreatment with Sophorolipid/BSA Supplementation. [PDF]

Polymers (Basel)
Xiong Y, Wang L, Zhou Q, Li F, He F, Liu R, Wang J, Zhan Z, Jia H, Xu C, Cai L.   +10 more
europepmc   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source