Results 61 to 70 of about 16,069,310 (302)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Cascade control algorithm of test bench for studying loadsensing electrohydraulic steering systems

MATEC Web of Conferences, 2018
The paper presents the design and synthesis of a three-loop cascade control system with a digital PI controller intended for installation in a test bench for load-sensing electrohydraulic steering units.
Mitov Alexander, Kralev Jordan, Angelov Ilcho   +2 more
doaj   +1 more source

Research of structure and control strategy of 6 kV chain STATCOM

Gong-kuang zidonghua, 2013
The paper proposed a design scheme of 6 kV chain static synchronous compensator. The compensator uses H-bridge cascade main circuit structure and carrier phase shifted sinusoidal pulse-width modulation, the AC side uses feed forward decoupling control ...
ZHOU Guo-dong
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Control of Corner Separation in Compressor Cascade Using Biomimetic Fish Scales Structure

Biomimetics
In this study, a fish scale structure with low viscous drag was proposed and applied to the suction surface of a compressor cascade to reduce total pressure loss and suppress corner separation, a key source of compressor inefficiency.
Jin-Long Shen, Szu-I Yeh
doaj   +1 more source

An Autonomous Design Method of a Cascade Structure Feedback Controller

IFAC-PapersOnLine, 2019
Abstract This paper proposes a method to design a wide-bandwidth cascade structure feedback (FB) controller for a mechatronic system with resonant modes. The notable feature of the proposed method is to optimally design both the structure and parameters of a FB controller that performs wide-bandwidth FB control while meeting the specified control ...
Eitaro Kuroda, Yoshihiro Maeda, Makoto Iwasaki   +2 more
openaire   +1 more source

Control of secondary flow structures on a highly loaded compressor cascade [PDF]

Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, 2013
This paper presents detailed flow-field measurements for a compressor cascade equipped with synthetic jet actuators for active flow control. The synthetic jets are mounted on the cascade sidewall and the suction side surface of the blade to reduce the total pressure loss caused by strong secondary flow structures developing in the passage.
Zander, Vincent, Nitsche, W.
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Event-Triggered H-Infinity Control for Continuous-Time Singular Networked Cascade Control Systems With State Delay

IEEE Access, 2020
This paper is concerned with the problems of modeling, stabilization, and H control for continuous-time singular networked cascade control systems (SNCCSs) with state delay and event-triggered control.
Zhaoping Du, Wen Li, Jianzhen Li, Xiaofei Yang   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source