Results 51 to 60 of about 2,468,009 (256)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Experimental Study on the Defrosting Energy Consumption of Cascade Air-source Heat Pump with Phase-change Energy Storage for Defrosting

Zhileng xuebao, 2019
This study explores the energy consumption during the defrosting process of a cascade air-source heat pump with phase-change energy storage for defrosting and from where it comes.
Qu Minglu, Zhang Rao, Zhang Tongyao, Li Tianrui   +3 more
doaj  

A study on the cycle variations of reversed Brayton cycle heat pumps for high-temperature heat supply to improve performance

Case Studies in Thermal Engineering
This study developed cycle configurations to improve the performance of a high-temperature heat pump based on a reversed Brayton cycle. Various configurations, including the heat recovery, cascade, and stepwise expansion cycles, were evaluated alongside ...
In Ho Chung, Jin Seo Kim, Tong Seop Kim, Chan Ho Song   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A novel ultra-low temperature cascade refrigeration with dual auxiliary loop to enhance thermal performance

Scientific Reports
A novel kind of cascade refrigeration cycle for ultra-low temperature applications has been proposed in the present work to enhance thermal performance with reduced carbon footprints more economically. The conventional cascade refrigeration system (CCRS)
Sachin Kumar, Pardeep Gahlot, Suresh Kumar, Aman Kumar   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Optimization of Mixed Fluid Cascade Natural Gas Liquefaction Plant Feed Stream Pressure [PDF]

Problems of the Regional Energetics
This paper presents the results of a study on optimising the feed stream pressure of the Mixed Fluid Cascade natural gas liquefaction cycle. The objective is to optimise the pressure of the feed stream to distribute heat effectively over the cooling ...
Ikonnikova A. Yu., Baranov A. Yu., Kravchenko D. V., Seredenko E. S.   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Phospho-regulation of the Neurospora crassa septation initiation network. [PDF]

PLoS ONE, 2013
Proper cell division is essential for growth and development of uni- and multicellular organisms. The fungal septation initiation network (SIN) functions as kinase cascade that connects cell cycle progression with the initiation of cytokinesis.
Yvonne Heilig, Kerstin Schmitt, Stephan Seiler   +2 more
doaj   +1 more source