Results 71 to 80 of about 2,468,009 (256)

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

The Scientific World Journal, 2011
A well-recognized theory of Alzheimer’s disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry ...
Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov   +2 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Cascade Wins From CCC's in Ninth Inning

, 1938
Recap of the baseball game between Cascade and CCC camp Gallagher, in which Cascade edged out the enrollees in the ninth ...
Cascade News
core  

Performance Study on Auto-cascade Absorption Refrigeration Cycle Using R32+R134a/DMF as Working Pairs

, 2006
The model was presented to investigate the performance of Auto-cascade Absorption Refrigeration Cycle(ACAR) using R32+R134a/DMF as working pairs in this study.The effects of the factors such as composition of working pairs,generation temperature ...
陈光明, 孟祥锋, 房杉
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Simulation of an Ammonia-Carbon Dioxide Transcritical Cascade Refrigeration System [PDF]

This study aims to evaluate the viability of employing ammonia (R717), a naturally existing refrigerant, within a transcritical cascade refrigeration configuration.
Majdi, Hasan Shakir, Saleh, Khalid, Hussen, Hasanen M., Rahman, Mokdad Hayawi   +3 more
core   +1 more source

Sub-cycle high-order nonlinearities in a terahertz quantum cascade laser

, 2022
Ultrafast electron dynamics in quantum cascade lasers hold enormous potential for the implementation of intense, compact mode-locked terahertz sources, squeezed terahertz light, frequency mixers, and comb-based metrology systems.
Li, LH, Riepl, J., Freeman, JR, Linfield, E., Dhillon, Sukhdeep, Freeman, J. R., Huber, R, Nong, H., Dhillon, S. S., Raab, J., Davies, A., Albes, T, Wacker, A, Abajyan, P., Abajyan, Pavel, Lange, C., Abajyan, P, Freeman, J., Wacker, A., Riepl, J, Dhillon, SS, Davies, A. G., Jirauschek, C., Li, L. H., Huber, R., Raab, J, Linfield, EH, Jirauschek, C, Davies, AG, Nong, H, Albes, T., Linfield, E. H., Lange, C, Li, L., Riepl, J.,, Dhillon, S. S.,, Davies, A. G.,, Albes, T.,, Jirauschek, C.,, Abajyan, P.,, Lund University., Nong, H.,, Raab, J.,, Freeman, J. R.,, Wacker, A.,, Linfield, E. H.,, Huber, R.,, Lange, C.,, Li, L. H.,   +48 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Cycle Analysis of Heating and Refrigeration in New Air-source Heat Pump

Zhileng xuebao, 2005
An air source heat pump operating in cascade cycle way was presented. The new-type heat pump can operate not only in a single-stage cycle, but also in a cascade cycle. The operation performance of the heat pump was stimulated.
王林, 陈光明, 陈斌, 王勤
doaj   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source