Results 121 to 130 of about 2,706,420 (286)

A Bi-enzymatic Convergent Cascade for epsilon-Caprolactone Synthesis Employing 1,6-Hexanediol as a "Double-Smart Cosubstrate'

, 2015
A bi-enzymatic cascade consisting of a Baeyer-Villiger monooxygenase and an alcohol dehydrogenase (ADH) was designed in a convergent fashion to utilise two molar equivalents of cyclohexanone (CHO) and one equivalent of 1,6-hexanediol as a 'double-smart ...
Hollmann, Frank, Frank Hollmann, Rajni Hatti‐Kaul, Bornadel, Amin, Amin Bornadel, Kara, Selin, Hatti-Kaul, Rajni,, Selin Kara, Hatti-Kaul, Rajni   +8 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines

Nature Communications
Biobased furans have emerged as chemical building blocks for the development of materials because of their diverse scaffolds and as they can be directly prepared from sugars.
Pritam Giri, Seonga Lim, Taresh P. Khobragade, Amol D. Pagar, Mahesh D. Patil, Sharad Sarak, Hyunwoo Jeon, Sangwoo Joo, Younghwan Goh, Seohee Jung, Yu-Jeong Jang, Seung Beom Choi, Ye Chan Kim, Taek Jin Kang, Yong-Seok Heo, Hyungdon Yun   +15 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Multi-enzyme cascade synthesis of the most odorous stereoisomers of the commercial odorant Muguesia (R)

, 2015
The most odorous stereoisomers of the chiral commercial fragrance Muguesie (R) are prepared by a very effective linear biocatalysed cascade reaction, in which a suitable unsaturated ketone is submitted to the sequential action of two enzymes, an ene ...
Monti Daniela, Parmeggiani Fabio, Santangelo Sara, Gatti Francesco G, Crotti Michele, Pugliese Andrea, Brenna Elisabetta   +6 more
core  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Improving the enzymatic activity and stability of N-carbamoyl hydrolase using deep learning approach

Microbial Cell Factories
Background Optically active D-amino acids are widely used as intermediates in the synthesis of antibiotics, insecticides, and peptide hormones. Currently, the two-enzyme cascade reaction is the most efficient way to produce D-amino acids using enzymes ...
Fa Zhang, Muhammad Naeem, Bo Yu, Feixia Liu, Jiansong Ju   +4 more
doaj   +1 more source

Gene cascade analysis in MAECs.

, 2015
The pathway map acquired from gene cascade analyses of quercetin-treated (50 μM) and untreated MAECs is shown. Black line + blue box represents enzymatic reaction or binding, red line + red box represents inhibition, black line + green box represents ...
Ryoko Nakayama (687120), Yoshinori Hasegawa (308240), Fumio Ide (687119), Yumi Ito (444413), Ayako Takahashi (687117), Ichiro Saito (269792), Kenji Mishima (269781), Koufuchi Ryo (687122), Hiroko Inoue (687118), Takashi Sakurai (171849), Ayaka Hasaka (687121)   +10 more
core   +1 more source