Results 41 to 50 of about 240,463 (263)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Incidence and Care Cascade of the Hepatitis C Virus in Korea

Gut and Liver, 2023
The 2030 hepatitis C virus (HCV) elimination targets of the World Health Organization are an 80% reduction in incidence and 65% reduction in mortality compared to the 2015 rates. However, information on the nationwide incidence and treatment rates of HCV infection are limited.
Young Eun Chon, Aejeong Jo, Eileen L. Yoon, Jonghyun Lee, Ho Gyun Shin, Min Jung Ko, Dae Won Jun   +6 more
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The cascade of care for Australians living with chronic hepatitis B: measuring access to diagnosis, management and treatment

Australian and New Zealand Journal of Public Health, 2015
Objective: To estimate the level of access to diagnosis, management and treatment for people living with chronic hepatitis B (CHB) in Australia, and to identify the gaps in clinical care for people living with CHB. Methods: Analysis of publicly available
Nicole L. Allard, Jennifer H. MacLachlan, Benjamin C. Cowie   +2 more
doaj   +1 more source

Hepatitis C virus care cascade among people who inject drugs in Puerto Rico: Minimal HCV treatment and substantial barriers to HCV care

Drug and Alcohol Dependence Reports, 2023
Background: People who inject drugs (PWID) in Puerto Rico are disproportionately affected by the hepatitis C virus (HCV) epidemic. However, there is a scarcity of data on the HCV care cascade among PWID in Puerto Rico. This study aims to describe the HCV
Yesenia Aponte-Meléndez, Pedro Mateu-Gelabert, Benjamin Eckhardt, Chunki Fong, Adriana Padilla, Wanda Trinidad-Martínez, Eric Maldonado-Rodríguez, Nancy Agront   +7 more
doaj   +1 more source

A Cascade of Care Model for Suicide Prevention

, 2021
The rising rates of suicide in the United States, particularly among young people of color, requires urgent attention. While the healthcare system is a critical service sector for suicide prevention given high levels of utilization by people at risk of suicide, it is not sufficient.
Emily E Haroz, Liina M. Sarapik, Leslie B. Adams, Paul Nestadt, Alison Athey, Eric Slade, Mary Cwik, Allan L. Berman, Holly Wilcox   +8 more
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Family Group Conferences as an alternative to Initial Child Protection Conferences for families on the Child Protection pathway: Synopsis

Health and Social Care Delivery Research
Background When children are at risk of significant harm due to abuse or neglect, local authority children’s services in the United Kingdom intervene to protect them and support families.
Lorna Stabler, Katrina Wyatt, Jo Day, Iain Lang, David Wilkins, Donald Forrester, Bekkah Bernheim, Alankrita Singh, Sarah O’Rourke, Jennie Hayes, Helene Prestat   +10 more
doaj   +1 more source

Statistical methods applied for the assessment of the HIV cascade and continuum of care: a systematic scoping review

BMJ Open, 2023
Objectives This scoping review aims to identify and synthesise existing statistical methods used to assess the progress of HIV treatment programmes in terms of the HIV cascade and continuum of care among people living with HIV (PLHIV).Design Systematic ...
Honorati Masanja, Kennedy Otwombe, Aneth Vedastus Kalinjuma, Tracy Renée Glass, Maja Weisser, Amina Suleiman Msengwa, Fiona Vanobberghen   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source