Results 31 to 40 of about 382,349 (195)

Mitigation strategies against cascading failures within a project activity network

, 2021
Successful on-time delivery of projects is a key enabler in resolving major societal challenges, such as wasted resources and stagnated economic growth.
Nicolaides, Christos
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mitigation strategies with feedback against cascading failures

, 2018
Because of the complexity and randomness of cascading failures, it is difficult to eliminate cascading failures and establish a robust network. However, we can sacrifice some unnecessary services to ensure the critical services of the network surviving ...
Yang Yang, Liang-Rui Tang, Run-Ze Wu, Bing Fan   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A markovian dependability model with cascading failures

, 2009
We develop a continuous-time Markov chain model of a dependability system operating in a randomly changing environment and subject to probabilistic cascading failures. A cascading failure can be thought of as a rooted tree.
Nakayama, Marvin K., Iyer, Srinivasan M., Gerbessiotis, Alexandros V.   +2 more
core   +1 more source

Cascading failures in complex networks

, 2020
Cascading failure is a potentially devastating process that spreads on real-world complex networks and can impact the integrity of wide-ranging infrastructures, natural systems and societal cohesiveness.
Zhang, Xin, Trunfio, Paul A, Valdez, Lucas Daniel, Braunstein, Lidia Adriana, Shekhtman, Louis, Havlin, Shlomo, Buldyrev, Sergey V., la Rocca, Cristian Ernesto   +7 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cascading Failures: Survival versus Prevention

, 2003
While measures can be taken to reduce the number of large-scale power losses due to failures of the generation and high-voltage transmission grid, such failures cannot be eliminated. The survival of essential missions is a more tractable problem than the
Sarosh Talukdar (5355377), Lester B Lave (5455793), M. Granger Morgan (1414822), Marija D. Ilic (4118302), Jay Apt (5046911)   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source