Results 161 to 170 of about 10,420,721 (307)

Evaluation of Tuberculosis Recurrence and Its Determinants in the Southeast of Iran: A Nested Case-Control Study Based on Data From 2012 to 2018

مجله اپیدمیولوژی ایران, 2020
Background and Objectives: In addition to effective treatment, tuberculosis recurrence is a very important challenge regarding the treatment of this infection. This study was conducted to evaluate the risk factors associated with tuberculosis recurrence.
B Moatamedizadeh, H Ansari, A Payandeh, SM Tabatabae, A Ramazanpouramirdehi   +4 more
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

MOESM2 of Identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a caseâ control validation study

, 2017
Additional file 2. Primers designed for validation of hub gene expression patterns by qPCR.
Li, Yiping, Li, Yanhong, Bai, Zhenjiang, Pan, Jian, Wang, Jian, Fang, Fang   +5 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect of Depressive Symptoms on Weight among Adults at Al-Najaf Province: A case-control Study

مجلة الكوفة الطبية
Background: Obesity and major depression disorder are two of the most common diseases in the world. They are also big problems because they have a very strong effect on people's health and well-being, but also because of their high morbidity and ...
Mohammed Abbas Mohammed, Salam Jasim Mohammed   +1 more
doaj   +1 more source

Additional file 1: of Risk factors of progressive IgA nephropathy which progress to end stage renal disease within ten years: a caseâ control study

, 2017
Stepwise multivariate logistic analysis. Contains detailed results in every step of stepwise multivariate logistic analysis. (DOCX 73 kb)
Danhua Shu, Feifei Xu, Su, Zhen, Zhang, Ji, Chaosheng Chen, Jianna Zhang, Xiaokai Ding, Yinqiu Lv, Haixia Lin, Peipei Huang   +9 more
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

MOESM1 of Identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a caseâ control validation study

, 2017
Additional file 1. Analysis of network topology for candidate soft-thresholding powers (βs).
Li, Yiping, Li, Yanhong, Bai, Zhenjiang, Pan, Jian, Wang, Jian, Fang, Fang   +5 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source