Results 81 to 90 of about 3,234,716 (247)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Matched case-control studies: a review of reported statistical methodology

Clinical Epidemiology, 2012
Daniel J Niven1, Luc R Berthiaume2, Gordon H Fick1, Kevin B Laupland11Department of Critical Care Medicine, Peter Lougheed Centre, Calgary, 2Department of Community Health Sciences, University of Calgary, Calgary, Alberta, CanadaBackground: Case-control ...
Niven DJ, Berthiaume LR, Fick GH, Laupl, KB   +4 more
doaj  

Tools for inventory control of dental supplies of a municipal health department

Brazilian Journal of Oral Sciences, 2019
Aim: Carry out a descriptive and organizational analysis of the Oral Health warehouse of the Municipal Health Department in a city in the South of Brazil in order to assist in its management.
Fernando Silva Guimarães, Chazele Barbosa dos Santos, Letycia Barros Gonçalves, Leandro Leitzke Thurow, Marysabel Pinto Telis Silveira   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Environmental epidemiology applied to urban atmospheric pollution: a contribution from the Experimental Air Pollution Laboratory (LPAE)

Cadernos de Saúde Pública, 2000
Systematic investigation on the effects of human exposure to environmental pollution using scientific methodology only began in the 20th century as a consequence of several environmental accidents followed by an unexpected mortality increase above ...
André Paulo Afonso de, Braga Alfésio Luis Ferreira, Lin Chin An, Conceição Gleice Margarete de Souza, Pereira Luiz Alberto Amador, Miraglia Simone Georges El Khouri, Böhm György Miklos   +6 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fatores associados à ideação suicida na comunidade: um estudo de caso-controle

Cadernos de Saúde Pública
Este estudo tem como objetivo identificar variáveis associadas à ideação suicida ao longo dos últimos 12 meses, na cidade de Campinas, São Paulo, Brasil.
Viviane Franco da Silva, Helenice Bosco de Oliveira, Neury José Botega, Letícia Marín-León, Marilisa Berti de Azevedo Barros, Paulo Dalgalarrondo   +5 more
doaj  

The impact of psychological stress on salivary cortisol levels in periodontitis patients: a case-control study

BMC Oral Health
Background Psychological stress is linked to elevated salivary cortisol levels, potentially worsening periodontitis by exacerbating inflammation. This study examines the impact of stress on cortisol levels in periodontitis patients, aiming to explore ...
Mozaffer Rahim Hingorjo, Muhammad Owais, Saad uddin Siddiqui, Shazia Nazar, Yumna Shaheen Ali   +4 more
doaj   +1 more source