Results 101 to 110 of about 3,234,716 (247)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Breastfeeding and breast cancer: a case-control study in Southern Brazil

Cadernos de Saúde Pública
To investigate the relationship between breastfeeding and breast cancer in Southern Brazil, a case-control design was employed, with two age-matched control groups. A total of 250 cases of breast cancer were identified in women from 20 to 60 years of age,
Sérgio Tessaro, Jorge U. Béria, Elaine Tomasi, Cesar G. Victora   +3 more
doaj  

Environmental and occupational cancer in Argentina: a case-control lung cancer study

Cadernos de Saúde Pública, 1998
The main objective of this study was to analyze the risks for lung cancer associated with occupational exposures in a developing country where lung cancer is the first cause of mortality from cancer in men. The study involved 200 men with lung cancer and
Matos Elena, Vilensky Marta, Boffetta Paolo   +2 more
doaj  

OUTBREAK OF HEPATITIS A: ASSOCIATED RISK FACTORS AND CONTROL MEASURES

Brazilian Journal of Infectious Diseases
Introduction/Objective: Hepatitis A (HA) is an infection caused by the hepatitis A virus (HAV). Transmission occurs predominantly through the fecal-oral route by ingestion of contaminated water or food and/or intimate contact with an infected individual.
Hoberdan Oliveira Pereira, Cristiane Hernandes da Silva, Cintia Faiçal Parenti, Cliviany Borges da Silva, Fernanda Fuscaldi Almeida, Paulo Roberto Lopes Correa, Silvio Luis Rodrigues de Almeida, Eva Lidia Arcoverde Medeiros, Amanda Aparecida Felizardo, Fabiana Francisca Alves, Bruna Walker Ferreira de Faria, Mário César Ferreira Lima Júnior, Tarso Menezes de Medeiros   +12 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Neutropenia, agranulocytosis and dipyrone

São Paulo Medical Journal
CONTEXT: Neutropenia and agranulocytosis may be defined as granulocyte counts of less than 1,500/mm³ and 500/mm³, respectively. Agranulocytosis is a rare and serious disease often caused by drugs. Its mortality rate is around 10%.
Nelson Hamerschlak, Alexandre Biasi Cavalcanti   +1 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Risk Factors for Hepatitis C Virus (HCV) Infection in Areas with a High Prevalence of HCV in the Republic of Korea in 2013

Gut and Liver, 2016
Background/AimsThe prevalence of hepatitis C virus (HCV) infection in Busan, Gyeongnam, and Jeonnam Provinces in Korea is more than twice the national average.
doaj   +1 more source