Results 111 to 120 of about 23,273,285 (322)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Preclinical obesity curriculum: audit, implementation, and evaluation

BMC Medical Education
Background This study aimed to (1) evaluate the current status of obesity education at Case Western Reserve University School of Medicine (CWRU) (2), introduce a comprehensive first-year curriculum on obesity, and (3) assess the impact of the curriculum ...
Amber Olson, Rosanna Watowicz, Eileen Seeholzer, Katherine Lyons, W. Scott Butsch, Colleen Croniger   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Detailed Case Study on Deviation, Out-of-Specification(OOS) and CAPA Generation in Pharmaceutical Industry

International Journal of Innovative Science and Research Technology
This review provide an overview of the various documentation of quality management system, which includes deviations, OOS and CAPA. A detailed case study of deviations, out-of-Specification and CAPA generation is beneficial for improving pharmaceutical ...
Arefa Khan, Anamika Singh, S. Malviya, Anil Kharia   +3 more
semanticscholar   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Active case finding with case management: the key to tackling the COVID-19 pandemic

The Lancet, 2020
Zhongjie Li, Qiulan Chen, Luzhao Feng, Lance E. Rodewald, Yinyin Xia, Hailiang Yu, Ruochen Zhang, Zhijie An, Wenwu Yin, Wei Chen, Ying Qin, Zhibin Peng, Ting Zhang, Daxin Ni, Jinzhao Cui, Qing Wang, Xiaokun Yang, Muli Zhang, Xiang Ren, Dan Wu, Xiaojin Sun, Yuanqiu Li, Lei Zhou, Xiaopeng Qi, Tie Song, George F. Gao, Zijian Feng, Zhongjie Qiulan Luzhao Lance Yinyin Hailiang Ruochen Wenwu Li Chen Feng Rodewald Xia Yu Zhang Yin Ni Qin Zhan, Zhongjie Li, Qiulan Chen, Luzhao Feng, Lance E. Rodewald, Yinyin Xia, Hailiang Yu, Ruochen Zhang, Wenwu Yin, Daxin Ni, Ying Qin, Ting Zhang, Jinzhao Cui, Qing Wang, Xiaokun Yang, Muli Zhang, Wei Chen, Zhibin Peng, Xiang Ren, Zhijie An, Dan Wu, Xiaojin Sun, Yuanqiu Li, Lei Zhou, Xiaopeng Qi, George F. Gao, Zijian Feng, Tie Song, Huiming Luo, Z. Yin, Li-ping Wang, Chao-Ying Ma, Shu Li   +59 more
semanticscholar   +1 more source

Systems Thinking and Design Thinking: The Search for Principles in the World We Are Making

She Ji: The Journal of Design, Economics and Innovation, 2019
While the concept of system has been part of design theory and practice from the beginning of the discipline, there is renewed interest today in the relationship of systems thinking and design.
Richard Buchanan
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The use of Coercive Interventions in Mental Health Care in Germany and the Netherlands. A comparison of the developments in two neighbouring countries

Frontiers in Public Health, 2014
In this review we compare the use of coercion in mental health care in Germany and in the Netherlands. Legal frameworks and published data on involuntary commitment, involuntary medication, seclusion, and restraint are highlighted as well as the role of ...
Tilman eSteinert, Tilman eSteinert, Eric eNoorthoorn, Cornelis L. Mulder   +3 more
doaj   +1 more source