Results 41 to 50 of about 161,419 (263)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Case Based Reasoning Untuk Diagnosis Penyakit Demam Berdarah

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, 2017
  Dengue virus is a virus that causes dengue fever (DD), dengue hemorrhagic fever (DBD) and dengue shock syndrome (SSD). This disease is included in the status of outbreaks at the Hospital Benjamin Guluh Kab. Kolaka.
Rabiah Adawiyah
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SimViz: Interactive visualizations to analyze similarity measures

SoftwareX
In Artificial Intelligence, similarity measures constitute a fundamental component across numerous methods and techniques. They play a particularly critical role in the retrieval process of Case-based Reasoning systems, where the quality of similarity ...
Guillermo Jimenez-Diaz, Belen Diaz-Agudo
doaj   +1 more source

Case Based Reasoning Diagnosis Hama dan Penyakit Tanaman Nilam

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, 2018
  Patchouli is an oil-producing plant asiri known as patchouli oil (oil patchouli oil) which has a high economic value and a bright prospect. Patchouli plants used as cosmetic ingredients, perfumes, antiseptics, soaps, drugs, and insecticides ...
Rabiah Adawiyah
doaj   +1 more source

Case-Based Reasoning Integrations.

AI Mag., 2002
This article presents an overview and survey of current work in case-based reasoning (CBR) integrations. There has been a recent upsurge in the integration of CBR with other reasoning modalities and computing paradigms, especially rule-based reasoning (RBR) and constraint-satisfaction problem (CSP) solving.
Marling, C, Sqalli, M, Rissland, E, Munoz-Avila, H, Aha, D   +4 more
openaire   +2 more sources

Emergent case-based reasoning applications [PDF]

The Knowledge Engineering Review, 2005
The basic principle underpinning case-based reasoning (CBR) is that new problems can be solved by reusing solutions to past problems. The generality of this idea means that CBR is finding application in a wide variety of areas.
Ramón López de Mántaras, Padraig Cunningham, Petra Perner   +2 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A decision support system for upper limb rehabilitation robot based on hybrid reasoning with RBR and CBR

Frontiers in Bioengineering and Biotechnology
The rehabilitation robot can assist hemiplegic patients to complete the training program effectively, but it only focuses on helping the patient’s training process and requires the rehabilitation therapists to manually adjust the training parameters ...
Sujiao Li, Sujiao Li, Shuhan Xiang, Qiqi Ma, Wenqian Cai, Suiyi Liu, Fanfu Fang, Hongliu Yu, Hongliu Yu   +8 more
doaj   +1 more source