Enabling case-based reasoning on the web of data
, 2017 While Case-based reasoning (CBR) has successfully been deployed on the Web, its data models are typically inconsistent with existing information infrastructure and standards. In this paper, we examine how CBR can operate on the emerging Web of Data, with
Heitmann, Benjamin, Hayes, Conor
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
A Pre-Generation of Emergency Reference Plan Model of Public Health Emergencies with Case-Based Reasoning. [PDF]
Risk Manag Healthc Policy, 2022 Ru D, Wen H, Zhang Y.
europepmc +1 more source
Preferences in Case-Based Reasoning
, 2016 Case-based reasoning (CBR) is a well-established problem solving paradigm that has been used in a wide range of real-world applications. Despite its great practical success, work on the theoretical foundations of CBR is still under way, and a coherent and universally applicable methodological framework is yet missing.
openaire +3 more sources
A Case with a View - Towards an Integration of Visual and Case-Based Reasoning in Design
, 2001 Despite the long-term effort to establish the theoretical foundations for Case-Based Reasoning (CBR) in design, it appears that additional theoretical efforts are needed in order to achieve the promise of this affinity. In this paper we argue that visual
R. Oxman, A. Heylighen
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
A case-based reasoning system for neonatal survival and LOS prediction in neonatal intensive care units: a development and validation study. [PDF]
Sci Rep, 2023 Kermani F +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Novel Case-Based Reasoning System for Public Health Emergencies. [PDF]
Risk Manag Healthc Policy, 2021 Duan J, Jiao F.
europepmc +1 more source