Results 231 to 240 of about 10,420,359 (296)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

The risk of infertility and dietary inflammatory index, a case-control study in Iran. [PDF]

open access: yesArch Gynecol Obstet
KabodMehri R   +11 more
europepmc   +1 more source

The Association Between Dietary Protein Intake and Gallstone Disease: A Case-Control Study. [PDF]

open access: yesGastroenterol Res Pract
Sadeghi A   +7 more
europepmc   +1 more source

Dysbiosis of the Saliva Microbiota in Patients with Psoriasis: A Case-Control Study. [PDF]

open access: yesJ Inflamm Res
Nielsen AB   +5 more
europepmc   +1 more source

Osteoarthritis, bronchial asthma, and periodontitis: is there a mutual influence? A 5-year case-control study. [PDF]

open access: yesBMC Oral Health
Semaan LB   +6 more
europepmc   +1 more source

Unveiling the risks and outcomes of preeclampsia: a case-control study in the UAE. [PDF]

open access: yesBMC Pregnancy Childbirth
Nandagopal P   +5 more
europepmc   +1 more source

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