Results 41 to 50 of about 9,722,382 (303)

Superdomains in the protein structure hierarchy: The case of PTP‐C2 [PDF]

open access: yesProtein Science, 2015
AbstractSuperdomain is uniquely defined in this work as a conserved combination of different globular domains in different proteins. The amino acid sequences of 25 structurally and functionally diverse proteins from fungi, plants, and animals have been analyzed in a test of the superdomain hypothesis.
Donald T, Haynie, Bin, Xue
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

A Dynamical Systems-Based Hierarchy for Shannon, Metric and Topological Entropy

open access: yesEntropy, 2019
A rigorous dynamical systems-based hierarchy is established for the definitions of entropy of Shannon (information), Kolmogorov−Sinai (metric) and Adler, Konheim & McAndrew (topological).
Raymond Addabbo, Denis Blackmore
doaj   +1 more source

Equality Cases of the Alexandrov–Fenchel Inequality Are Not in the Polynomial Hierarchy

open access: yesProceedings of the 56th Annual ACM Symposium on Theory of Computing
Abstract Describing the equality conditions of the Alexandrov–Fenchel inequality [Ale37] has been a major open problem for decades. We prove that in the case of convex polytopes, this description is not in the polynomial hierarchy unless the polynomial hierarchy collapses to a finite level.
Swee Hong Chan, Igor Pak
openaire   +5 more sources

DOES HIERARCHY STILL MATTER?

open access: yes, 2023
reservedThis thesis regards hierarchy and its role in organizations. It will be discussed both the advantages and drawbacks of adopting a hierarchical structure instead of a flat one.
MUNARO, NICOLA
core  

Motivation Maslow’s hierarchy of needs [PDF]

open access: yes, 2022
Maslow’s Hierarchy of needs is a theory implemented by various organizations globally to motivate its employees. The thirty year old theory has been widely used and is gaining popularity during the months of this global pandemic where employee motivation
Mehta, Dhruv
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Characterization of Quantum Correlations with Local Dimension Constraints and Its Device-Independent Applications

open access: yesPhysical Review X, 2014
The future progress of semi-device-independent quantum information science depends crucially on our ability to bound the strength of the nonlocal correlations achievable with finite-dimensional quantum resources.
Miguel Navascués   +2 more
doaj   +1 more source

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