Results 61 to 70 of about 9,722,382 (303)

A Boolean Algebra Approach for Class Hierarchy Normalization [PDF]

, 1997
Normalization in object-oriented design is much different from that in relational database design. Not only are the conceptual data model of object-oriented (o-o) models integrating richer structuring capabilities than that of relational models, but also
Jitian Xiao, Xiao, Jitian, Yanchun Zhang, Zhang, Yanchun   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

KdV hierarchies and quantum Novikov's equations [PDF]

Open Communications in Nonlinear Mathematical Physics
This paper begins with a review of the well-known KdV hierarchy, the $N$-th Novikov equation, and its finite hierarchy in the classical commutative case. This finite hierarchy consists of $N$ compatible integrable polynomial dynamical systems in $\mathbb{
V. M. Buchstaber, A. V. Mikhailov
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mixed spectral AKNS hierarchy from linear isospectral problem and its exact solutions

Open Physics, 2015
In this paper, the AKNS isospectral problem and its corresponding time evolution are generalized by embedding three coefficient functions. Starting from the generalizedAKNS isospectral problem, a mixed spectralAKNS hierarchy with variable coefficients is
Zhang Sheng, Gao Xu-Dong
doaj   +1 more source

Infinite hierarchy of nonlinear Schrödinger equations and their solutions [PDF]

, 2016
We study the infinite integrable nonlinear Schrödinger equation hierarchy beyond the Lakshmanan-Porsezian-Daniel equation which is a particular (fourth-order) case of the hierarchy.
Ankiewicz, Adrian, Bandelow, U., Akhmediev, Nail, Kedziora, David, Chowdury, Atiqur, Bandelow, Uwe, Bandelow, U, Kedziora, DJ, Akhmediev, N, Chowdury, Amdad, Chowdury, A, Ankiewicz, A, Kedziora, David Jacob   +12 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Case for a Considered Hierarchy of Discrimination Grounds in EU Law [PDF]

Maastricht Journal of European and Comparative Law, 2006
The EU has legislation, based on Article 13 EC, against discrimination on the grounds of sex, racial and ethnic origin, religion or belief, disability, age and sexual orientation, but the protection provided is not the same for all these grounds. It can be said that this EU legislation creates a hierarchy of discrimination grounds, with racial or ...
openaire   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

THE HIERARCHY AND COMPETITION OF PRINCIPLES OF LAW: METHODOLOGICAL PROBLEMS

Правовое государство: теория и практика
The relevance of the research topic is determined by the presence of a wide range of scientific literature devoted to the principles of law, but at the same time the lack of study of the interrelated problems of their hierarchy and competition.
ILYUKHINA Vera Aleksanovna
doaj   +1 more source