Results 31 to 40 of about 844,974 (290)

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Animal Experimentation in Basic Research – Current Discussion and Implications of the Latest Jurisprudence in Switzerland

Journal of Animal Law, Ethics and One Health
In recent years a discernible political trend has developed, particularly in Europe and the United States, towards phasing out or at least significantly reducing the use and harm of animals in research.
Nicole Lüthi, Katerina Stoykova, Margot Michel   +2 more
doaj   +1 more source

Set-off as a way of ending obligations [PDF]

Glasnik Advokatske komore Vojvodine, 2015
In this work the authors analyzed set-off as one of the most common and most significant way of ending obligations in our legal system. The most important and in practice the most common way of ending obligations is their fulfillment.
Radovanov Aleksandar, Danojlić Miladin
doaj  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

A note of caution on CJEU databases

European Law Open
The purpose of this short research note is to draw attention to two major pitfalls of working with databases of decisions of the Court of Justice of the European Union.
Michal Ovádek
doaj   +1 more source

Peculiarities of Trade Secrets Protection in Public Procurement

Teisė, 2019
This article deals with the legal regulation of the obligation to protect confidential information in public procurement procedures and the peculiarities of the application of trade secrets in these relations.
Ramūnas Birštonas, Karolis Šimanskis
doaj   +1 more source

GUARANTEEING THE ACCES OF THIRD PARTIES TO THE NETWORK INDUSTRIES SPECIFIC INFRASTRUCTURES – A VITAL COMPONENT OF EU'S POLICY IN THE FIELD OF COMPETITION ON THE ENERGY MARKET, IN THE CONTEXT OF THE NEED TO INSURE ENERGY INDEPENDENCE WHILE MANTAINING AFFORDABLE PRICES [PDF]

Challenges of the Knowledge Society, 2023
As both the practical experience and the theoretical constructions of successive generations of practitioners and researchers of the phenomenon of the economy and the legal norms associated with its proper functioning have proven, the most important ...
Iulian BĂICULESCU, Dragoș-Adrian BANTAȘ   +1 more
doaj  

(Un)Conditional Welfare? Tensions Between Welfare Rights and Migration Control in Swiss Case Law

Swiss Journal of Sociology, 2021
This analysis of Swiss Federal Supreme Court judgements shows the coupling of welfare and migration control. Foreign nationals depending on social assistance might face the withdrawal of their residence permits.
Borrelli Lisa Marie, Kurt Stefanie, Achermann Christin, Pfirter Luca   +3 more
doaj   +1 more source