Results 41 to 50 of about 2,079,141 (264)

Development and implementation of an integrated chronic disease model in South Africa: lessons in the management of change through improving the quality of clinical practice

International Journal of Integrated Care, 2015
Background: South Africa is facing a complex burden of disease arising from a combination of chronic infectious illness and non-communicable diseases. As the burden of chronic diseases (communicable and non-communicable) increases, providing affordable ...
Ozayr Mahomed, Shaidah Asmall
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

When better data meets better design: How EHR data usability and system usability shape physicians’ cognitive load

npj Digital Medicine
Electronic health record (EHR) systems were designed to enhance clinical decision-making, yet the way data is organized and displayed can create significant cognitive demands for physicians.
Curtis A. Merriweather, Jr., Kalle Lyytinen, David Aron, Michael R. Cauley   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Institutions as Objects in Fourth Order Design

She Ji: The Journal of Design, Economics and Innovation
Fourth order design, which involves systems and environments, is a frequently misunderstood area of design. The concept of institution offers a way to clarify and enrich fourth order design in both theory and practice.
Kipum Lee
doaj   +1 more source

Does a public single payer system deliver integrated care? A national survey study among professional stakeholders in Denmark

International Journal of Integrated Care, 2008
Background: Integrated health care delivery is a goal of health care systems; to date there has been limited information on the integration of medical care in practice.
Martin Strandberg-Larsen, Allan Krasnik
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Preclinical obesity curriculum: audit, implementation, and evaluation

BMC Medical Education
Background This study aimed to (1) evaluate the current status of obesity education at Case Western Reserve University School of Medicine (CWRU) (2), introduce a comprehensive first-year curriculum on obesity, and (3) assess the impact of the curriculum ...
Amber Olson, Rosanna Watowicz, Eileen Seeholzer, Katherine Lyons, W. Scott Butsch, Colleen Croniger   +5 more
doaj   +1 more source

Case management of cholera

Vaccine, 2020
Cholera still affects about three million people a year and kills approximately 100,000. Cholera can be effectively managed in the majority of cases with oral rehydration solution alone. Up to one third of patients present with severe dehydration, which can be diagnosed clinically, and will require rapid intravenous rehydration with Ringers Lactate or ...
openaire   +2 more sources