Results 111 to 120 of about 7,266 (305)

THE TREATMENT OF AMBULATORY GYNECOLOGIC CASES. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1898
Sanger tells us that gynecology is the surgery of the female genitalia. His definition is neither exact nor complete, but it is clinically useful. As a matter of fact the first thing to be determined in every gynecologic case is the advisability of operation. A necessary subdivision of the question is at once apparent.
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Numerical Investigation of Inlet Distortion on an Axial Flow Compressor Rotor with Circumferential Groove Casing Treatment

open access: yes, 2008
On the base of an assumed steady inlet circumferential total pressure distortion, three-dimensional time-dependent numerical simulations are conducted on an axial flow subsonic compressor rotor.
Wu Hu, Huang Jian, Jian, Huang, Hu, Wu
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Performance Enhancement of a Transonic Axial Flow Compressor with Circumferential Casing Grooves to Improve the Stall Margin

open access: yesJournal of Applied Fluid Mechanics, 2020
The stability range of the gas turbine engine compressors is being challenged in the modern days due to the intention of increasing per stage maximum loading.
N. Ahmad   +4 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Alleviation of spike stall in axial compressors utilizing grooved casing treatment

open access: yes, 2015
This article deals with application of grooved type casing treatment for suppression of spike stall in an isolated axial compressor rotor blade row. The continuous grooved casing treatment covering the whole compressor circumference is of 1.8mm in depth ...
Abbasi, Sarallah, Taghavi-Zenouz, Reza
core   +1 more source

Lessons Learned from Wellbore Integrity in Fuling Shale Gas Field

open access: yesShiyou jixie, 2018
To ensure the safe development of shale gas horizontal wells in the Fuling shale gas field, a calculation method of effective external load of shale gas horizontal well production casing and a optimization design of the production casing string was ...
Wang Guanglei   +2 more
doaj  

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