Results 71 to 80 of about 11,840,309 (376)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

TREATMENT OF TETANUS [PDF]

open access: yesJournal of the American Medical Association, 1918
History. —N. B., a white man, aged 24, was admitted to the hospital, May 24, 1918, complaining of stiffness in his jaws, but still able to talk. He was a shoemaker, but for the past three months had been working as watchman at one of the railroad stations. The family history was negative.
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Improving the production and quality of white button mushroom (Agaricus bisporus) by adding biochar and ash to the casing layer

open access: yesTikrit Journal for Agricultural Sciences
This investigation was implied to assess the effect of adding different rates of biochar and ash (0, 5, 10, 20 g L -1 casing layer) at the casing layer on production and quality indicator (total yield, biological efficiency, earliness of pinhead and ...
Bnar J. Jalal, Mustafa R. M. Alqaisi
doaj   +1 more source

Casting propellant in rocket engine [PDF]

open access: yes, 1976
A method is described for casting a solid propellant in the casing of a rocket engine having a continuous wall with a single opening which is formed by leaves of a material which melt at a temperature of the propellant and with curved edges concentric to
Froehling, S. C., Roach, J. E.
core   +1 more source

The effect of hydrogen sulphide on ammonium bisulphite when used as an oxygen scavenger in aqueous solutions [PDF]

open access: yes, 2011
Peer ...
Akisanya, Alfred Rotimi   +3 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

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