Results 181 to 190 of about 333,383 (311)

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Advanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu   +13 more
wiley   +1 more source

IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor

, 1999
Giamila Fantuzzi, David Reed, Charles A. Dinarello   +2 more
openalex   +1 more source

Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs [PDF]

, 1999
Preet M. Chaudhary, Michael Eby, Alan Jasmin, Leroy Hood   +3 more
openalex   +1 more source

Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells. [PDF]

Sci Rep
Luo Y, Li J, Fu Q, Zhang P, Song X, Liu M, Mo R, Fu J, Tang S, Wu J, Yang X, Liu X, Wang T, Ni G.   +13 more
europepmc   +1 more source

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng   +21 more
wiley   +1 more source

Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
wiley   +1 more source

Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis [PDF]

, 1998
Liang‐Ping Weng, Junying Yuan, Qiang Yu   +2 more
openalex   +1 more source

The Effect of Bovine Viral Diarrhoea Virus Biotypes on Bovine Oocyte In Vitro. [PDF]

Vet Med Sci
Roshanzamir A, Talebkhan Garoussi M, Mehrzad J.   +2 more
europepmc   +1 more source

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Advanced Science, EarlyView.
NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional Runx2 (exon 6‐exclusive) isoforms to reinforce osteoblast differentiation.
Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei   +9 more
wiley   +1 more source

Expression of Caspase and BCL-2 Apoptotic Family Members in Mouse Preimplantation Embryos1

, 1999
Ginger E. Exley, Chaoyu Tang, Abigail S. McElhinny, Carol M. Warner   +3 more
openalex   +1 more source