Results 191 to 200 of about 333,383 (311)

Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells [PDF]

, 1999
Xue-min ZHANG, Hong Lin, Catheryne Chen, Ben D.‐M. Chen   +3 more
openalex   +1 more source

Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice. [PDF]

Front Immunol
Pilot T, Solier S, Jalil A, Magnani C, Vanden Berghe T, Vandenabeele P, Masson D, Solary E, Thomas C.   +8 more
europepmc   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Mechanisms of pyroptosis in modulating osteoblast function under simulated microgravity. [PDF]

BMC Musculoskelet Disord
Wang M, Xue J, Liu S, Xu C, Cao Z, Yu H, Nong X, Huang K, Hu S, Guo Y, Han B.   +10 more
europepmc   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source

Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease [PDF]

, 1999
Sic L. Chan, W. Sue T. Griffin, Mark P. Mattson   +2 more
openalex   +1 more source

Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology. [PDF]

Sci Rep
Niu Q, Zhang T.
europepmc   +1 more source

Genetically Engineered IL12/CSF1R‐Macrophage Membrane‐Liposome Hybrid Nanovesicles for NIR‐II Fluorescence Imaging‐Guided and Membrane‐Targeted Mild Photothermal‐Immunotherapy of Glioblastoma

Advanced Science, EarlyView.
A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen, Yue Liu, Haiyan Huang, Menglong Li, Hui Xie, Shubham Roy, Jingsi Gu, Jian Jin, Kai Deng, Lixin Du, Bing Guo   +10 more
wiley   +1 more source

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID [PDF]

, 1999
Susan L Wang, Christine J. Hawkins, Soon Ji Yoo, H.‐Arno J. Müller, Bruce A. Hay   +4 more
openalex   +1 more source

Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities. [PDF]

Biomark Res
Miao R, Wang X, Zhang J, Kang Q, Liu Q, Luo X, Hou J, Gao B.   +7 more
europepmc   +1 more source