Results 201 to 210 of about 526,882 (310)

PANoptosis: a potential target of cardiomyopathy. [PDF]

Front Immunol
Sun M, Lu C, Wei J, Gao C, Dong D.
europepmc   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Mesenchymal Stem Cells Derived from Different Adipose Tissue Depots Ameliorate Severe Acute Pancreatitis by Inhibiting NF-κB/NLRP3/Caspase-1 Pathways [PDF]

Ao Wang, Yu An, Xuefei Wang, Wenfeng Gou, Feifei Xu, Yanli Li, Cong Wang, Zhengwei Tu, Wenbin Hou, Yunfeng Cui   +9 more
openalex   +1 more source

GSDME in cardiovascular diseases: research system and contemporary progress. [PDF]

Front Immunol
Yang Z, Luo Z, Zhang H, Zong J, Huang P, Niu Y, Zhou C, Wang S, Zhang D.   +8 more
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis [PDF]

, 1997
L. Miguel Martins, Peter W. Mesner, Timothy Kottke, Guriqbal S. Basi, Sukanto Sinha, Jay S. Tung, Phyllis A. Svingen, Benjamin J. Madden, Atsushi Takahashi, Daniel McCormick, William C. Earnshaw, Scott H. Kaufmann   +11 more
openalex   +1 more source

The omega-3 DHA induces pyroptosis and mitochondrial dysfunction in ovarian cancer cells via ROS and caspase-1 activation. [PDF]

Cell Death Discov
Pasquarelli-do-Nascimento G, Bezerra SP, Manchine JP, Lago NCS, Braz-de-Melo HA, Soares da Cruz N, Bellozi PMQ, Rocha AP, Santos IO, Lago FG, Machado SA, Nicola AM, de Bem AF, Báo SN, Magalhães KG.   +14 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Differentiating the Substrate Profiles of Inflammatory Caspases Using Extended Förster Resonance Energy Transfer-Based Peptide Substrates. [PDF]

Chembiochem
Boyd TC, Young SF, Lusis TL, Fegaras MA, Alani R, Shelley K, Southern CA, Karver CE.   +7 more
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source