Results 281 to 290 of about 333,383 (311)

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection. [PDF]

EMBO J
Yeap HW, Goh GR, Rosli SN, Pung HS, Giogha C, Eng VV, Pearson JS, Hartland EL, Chen KW.   +8 more
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Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis. [PDF]

Front Cell Dev Biol
Mei J, Xiao N, Xi Y, Chen X, Zha X, Cui L, Yan F, Xue R, Wang Y, Ma Y.   +9 more
europepmc   +1 more source

Carotenoids Modulate FoxO-Induced Cell Cycle Awrrest in Human Cancer Cell Lines: A Scoping Review. [PDF]

Food Sci Nutr
Lee ZX, Guo H, Looi AD, Bhuvanendran S, Magalingam KB, Lee WL, Radhakrishnan AK.   +6 more
europepmc   +1 more source

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Caspases and caspase inhibitors

Trends in Biochemical Sciences, 1997
Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and ...
Pascal Villa, William C. Earnshaw, Scott H. Kaufmann   +2 more
openaire   +3 more sources

Caspases

Current Protocols in Protein Science, 2001
AbstractCaspases are a family of cysteine proteases with a strict specificity for aspartate residues involved in inflammatory process and programmed cell death. This overview unit provides basic information on their structure, enzymatic activity, substrate specificity, activation,inhibition and their implication in pathologies.
Guy S. Salvesen, Jean-Bernard Denault
openaire   +3 more sources

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

Nature Medicine, 2000
Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
Timothy S. Zheng, Stéphane Hunot, Donald W. Nicholson, Yuri Lazebnik, Richard A. Flavell, Takashi Momoi, Anu Srinivasan, Keisuke Kuida   +7 more
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Caspases — An update

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Caspases belong to a family of highly conserved aspartate-specific cysteine proteases and are members of the interleukin-1beta-converting enzyme family, present in multicellular organisms. The caspase gene family consists of 15 mammalian members that are grouped into two major sub-families, namely inflammatory caspases and apoptotic caspases.
Binu Tharakan, Ganapathy K. Bhat, Indrajit Chowdhury   +2 more
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The insect caspases

Apoptosis, 2009
Developmental and tissue homeostasis is a delicate balance between cell proliferation and cell death. The activation of caspases, a conserved family of cysteine proteases, is a main event in the initiation and execution of programmed cell death. While caspases have been characterized from many organisms, comparatively little is known about insect ...
Carl Lowenberger, Dawn Cooper, David J. Granville   +2 more
openaire   +3 more sources