Results 311 to 320 of about 514,126 (359)
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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Nature, 2019Lars M Schiffmann, , Martin Krönke
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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Nature, 2019Kim Newton +2 more
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Molecular mechanisms of caspase regulation during apoptosis
Nature Reviews Molecular Cell Biology, 2004S. Riedl, Yigong Shi
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Activity of caspase-8 determines plasticity between cell death pathways
Nature, 2019Kim Newton, Debra L Dugger, Yue Zhang
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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Nature, 2004Sanjeev Mariathasan +2 more
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Caspase‐3: Structure, function, and biotechnological aspects
Biotechnology and applied biochemistry, 2021Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until
M. Asadi +6 more
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Caspases and caspase inhibitors
Trends in Biochemical Sciences, 1997Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and ...
Pascal Villa +2 more
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Current Protocols in Protein Science, 2001
AbstractCaspases are a family of cysteine proteases with a strict specificity for aspartate residues involved in inflammatory process and programmed cell death. This overview unit provides basic information on their structure, enzymatic activity, substrate specificity, activation,inhibition and their implication in pathologies.
Guy S. Salvesen, Jean-Bernard Denault
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AbstractCaspases are a family of cysteine proteases with a strict specificity for aspartate residues involved in inflammatory process and programmed cell death. This overview unit provides basic information on their structure, enzymatic activity, substrate specificity, activation,inhibition and their implication in pathologies.
Guy S. Salvesen, Jean-Bernard Denault
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Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
Nature Medicine, 2000Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. Using an established in vivo model of Fas-mediated apoptosis, we demonstrate here that elimination of certain caspases was compensated in vivo by the activation of other ...
Timothy S. Zheng +7 more
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Caspases belong to a family of highly conserved aspartate-specific cysteine proteases and are members of the interleukin-1beta-converting enzyme family, present in multicellular organisms. The caspase gene family consists of 15 mammalian members that are grouped into two major sub-families, namely inflammatory caspases and apoptotic caspases.
Binu Tharakan +2 more
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Caspases belong to a family of highly conserved aspartate-specific cysteine proteases and are members of the interleukin-1beta-converting enzyme family, present in multicellular organisms. The caspase gene family consists of 15 mammalian members that are grouped into two major sub-families, namely inflammatory caspases and apoptotic caspases.
Binu Tharakan +2 more
openaire +3 more sources