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Pyroptosis in Alzheimer's Disease: Mechanisms and Therapeutic Potential. [PDF]

Cell Mol Neurobiol
Tang T.
europepmc   +1 more source

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Caspase‐3: Structure, function, and biotechnological aspects

Biotechnology and applied biochemistry, 2021
Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until
M. Asadi, Saeed Taghizadeh, Elina Kaviani, Omid Vakili, M. Taheri‐Anganeh, Mahshid Tahamtan, A. Savardashtaki   +6 more
semanticscholar   +1 more source

Regulation of cell death protease caspase-9 by phosphorylation.

Science, 1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells.
M. Cardone, N. Roy, H. Stennicke, G. Salvesen, T. Franke, E. Stanbridge, S. Frisch, John Calvin Reed   +7 more
semanticscholar   +1 more source

Biochemical pathways of caspase activation during apoptosis.

Annual Review of Cell and Developmental Biology, 1999
Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase activation have been recently elucidated.
I. Budihardjo, H. Oliver, M. Lutter, Xu Luo, Xiaodong Wang   +4 more
semanticscholar   +1 more source

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nature, 2015
N. Kayagaki, Irma B. Stowe, Bettina L. Lee, K. O’Rourke, Keith Anderson, S. Warming, Trinna L Cuellar, B. Haley, M. Roose-Girma, Q. Phung, Peter S. Liu, J. Lill, Hong Li, Jiansheng Wu, S. Kummerfeld, Juan Zhang, Wyne P. Lee, S. Snipas, G. Salvesen, L. X. Morris, L. Fitzgerald, Yafei Zhang, E. Bertram, C. Goodnow, V. Dixit   +24 more
semanticscholar   +1 more source

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Nature, 1998
M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, S. Nagata   +5 more
semanticscholar   +1 more source

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Nature, 2000
T. Nakagawa, Hong Zhu, N. Morishima, En Li, Jin Xu, B. Yankner, Junying Yuan   +6 more
semanticscholar   +1 more source

Non-canonical inflammasome activation targets caspase-11

Nature, 2011
N. Kayagaki, S. Warming, M. Lamkanfi, L. Walle, S. Louie, Jennifer Dong, K. Newton, Yan Qu, Jinfeng Liu, Sherry Heldens, Juan Zhang, Wyne P. Lee, M. Roose-Girma, V. Dixit   +13 more
semanticscholar   +1 more source