Results 181 to 190 of about 578,452 (308)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Huntingtin in the amygdaloid basolateral complex is correlated with Vonsattel staging in Huntington's disease. [PDF]

open access: yesBrain Commun
Sanchez-Migallon P   +10 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

Identifying the exposure of taxonomic, functional, and phylogenetic diversity of steppe birds to renewable energy development

open access: yesConservation Biology, EarlyView.
Abstract Biodiversity is globally threatened by human impacts, including land‐use transformation and climate change, which has prompted a rapid transition from fossil fuels to cleaner energy sources, such as photovoltaic (PV) energy. However, utility‐scale PV plants require vast areas and can lead to conflicts with biodiversity conservation, making ...
Pablo Medrano‐Vizcaíno   +10 more
wiley   +1 more source

Castilla y Vizcaya

open access: yes, 1889
Papel. - Artículo publicado en El Noticiero Bilbaíno (Bilbao). - Procedencia: fondo Miguel de Unamuno. - Conservación: Buena.
openaire   +1 more source

Contact Sensitization in Patients With Frontal Fibrosing Alopecia: Patch Test Results With an Extended Baseline Series in Consecutive Patients

open access: yesContact Dermatitis, EarlyView.
Sensitization to propolis, shellac and gallate mix is FFA‐associated, but its relevance is largely unknown. Sensitization to salicylates is frequent and associated with symptoms of intolerance to sun exposure or sunscreens. No significant improvement by allergen avoidance is identified.
María‐Antonia Pastor‐Nieto   +11 more
wiley   +1 more source

Does nature shape risk preferences? Evidence from Chile, Norway, and Tanzania

open access: yesEconomic Inquiry, Volume 63, Issue 2, Page 568-590, April 2025.
Abstract Does exposure to a more risky environment affect risk preferences? Going beyond single‐case study evidence, we report results from five surveys conducted in three countries and link this with administrative data to study whether a link between exposure and preferences is detectable and widespread. We find no evidence for endogenous preferences
Florian Diekert, Robbert‐Jan Schaap
wiley   +1 more source

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