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CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

Nature Communications, 2022
Idiopathic multicentric Castleman disease (iMCD) is a rare and poorly-understood cytokine storm-driven inflammatory disorder. Interleukin-6 (IL-6) is a known disease driver in some patients, but anti-IL-6 therapy with siltuximab is not effective in all ...
Sheila K Pierson, Melanie D Mumau
exaly   +2 more sources

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Imaging of Castleman Disease.

Radiographics, 2023
Castleman disease (CD) is a group of rare and complex lymphoproliferative disorders that can manifest in two general forms: unicentric CD (UCD) and multicentric CD (MCD).
M. Pitot, Ali D Tahboub Amawi, L. Alexander, J. LeGout, L. Walkoff, P. Navin, A. Kawashima, A. Wood, A. Dispenzieri, S. Venkatesh   +9 more
semanticscholar   +1 more source

Recent Advances in Castleman Disease

Oncology Research and Treatment, 2022
Background: Castleman disease (CD) encompasses a spectrum of rare disorders with characteristic histopathological features. Unicentric CD (UCD) is a benign, local hyperplasia of lymphoid tissue that is usually curable.
C. Hoffmann, M. Hentrich, M. Tiemann, A. Rosenwald, F. Weber, W. Willenbacher, K. Hübel   +6 more
semanticscholar   +1 more source

Castleman disease

Current Opinion in Hematology, 2007
Castleman disease was initially described over 50 years ago as a benign localized mass of lymph nodes found primarily in the mediastinum of asymptomatic patients. Subsequently, additional types were recognized that extend the spectrum of this heterogeneous group of diseases. Optimal standard therapies have not been established. Currently, most patients
Anu, Dham, Bruce A, Peterson
openaire   +4 more sources

Idiopathic multicentric Castleman disease with TAFRO clinical subtype responsive to IL‐6/JAK inhibition: A pediatric case series

Pediatric Blood & Cancer, 2021
TAFRO (thrombocytopenia, anasarca, fever/elevated C‐reactive protein, reticulin myelofibrosis, renal dysfunction, and organomegaly) clinical subtype of idiopathic multicentric Castleman disease (iMCD‐TAFRO) is a rare lymphoproliferative disease ...
H. Lust, Shunyou Gong, Allison Remiker, Jenna Rossoff   +3 more
semanticscholar   +1 more source

The full spectrum of Castleman disease: 273 patients studied over 20 years

British Journal of Haematology, 2018
Eric Oksenhendler, David Boutboul, David C Fajgenbaum   +2 more
exaly   +2 more sources

Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?

American Journal of Hematology, 2019
Castleman disease (CD) is a rare lymphoproliferative disorder that can be unicentric or multicentric. Multicentric CD (MCD) is further subdivided into human herpesvirus type‐8‐associated, POEMS syndrome‐associated, and idiopathic (iMCD).
Tomoyuki Sakai, Hiroshi Kawabata, Nozomu Kurose   +2 more
exaly   +2 more sources

Castleman Disease Pathogenesis

Hematology/Oncology Clinics of North America, 2018
Castleman disease (CD) describes a group of heterogeneous disorders with common lymph node histopathologic features, including atrophic or hyperplastic germinal centers, prominent follicular dendritic cells, hypervascularization, polyclonal lymphoproliferation, and/or polytypic plasmacytosis.
David C, Fajgenbaum, Dustin, Shilling
openaire   +2 more sources

Idiopathic multicentric Castleman disease (iMCD)‐idiopathic plasmacytic lymphadenopathy: A distinct subtype of iMCD‐not otherwise specified with different clinical features and better survival

British Journal of Haematology
Idiopathic multicentric Castleman disease (iMCD) is subclassified into iMCD‐thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) and iMCD‐not otherwise specified (NOS) according to the Castleman Disease Collaborative ...
Yu-han Gao, Yan-ting Liu, Miao-yan Zhang, Si-yuan Li, D. Fajgenbaum, Lu Zhang, Jian Li   +6 more
semanticscholar   +1 more source

Retroperitoneal Castleman's Disease

Urology, 2010
A 56-year-old postmenopausal woman with a history of colon cancer status after left hemicolectomy presented to our institution with abdominal pain, early satiety, and weight loss. Computerized tomography scan showed a large, enhancing, fat-containing mass displacing the left kidney posteriolaterally suspicious for a retroperitoneal liposarcoma.
A Ari, Hakimi, Izak, Faiena, Ronald N, Kaleya, Reza, Ghavamian   +3 more
openaire   +2 more sources