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New developments in castrate‐resistant prostate cancer
BJU International, 2012Castrate‐resistant prostate cancer (CRPC) occurs when disease progresses in the presence of castrate levels of androgens and remains sensitive to further hormonal manipulation. For many years the treatment of CRPC was limited to the use of docetaxel for metastatic disease.
Shore, N., Mason, M., de Reijke, Th M.
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Emerging therapies in castrate-resistant prostate cancer
Current Opinion in Oncology, 2009Prostate cancer continues to represent a major health problem. It represents the most common cancer in US men, with an estimated 186 320 new cases diagnosed in 2008. It is the second leading cause of cancer death in men in the United States. Despite several attempts, the median survival for men with metastatic castrate-resistant prostate cancer is 1-2 ...
Kiran, Lassi, Nancy A, Dawson
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The Molecular Evolution of Castration-resistant Prostate Cancer
European Urology Focus, 2016Androgen deprivation therapy (ADT) is the backbone of treatment for advanced prostate cancer. However, castration-resistant prostate cancer (CRPC) nearly invariably develops through a range of different molecular mechanisms accompanied by progression to a more aggressive phenotype.To understand the key molecular mechanisms leading to CRPC and the ...
Yvonne, Ceder +5 more
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Satraplatin for the Therapy of Castration-Resistant Prostate Cancer
Future Oncology, 2009While docetaxel-based chemotherapy improves survival in patients with castration-resistant prostate cancer, all of these patient's cancers will eventually progress and other active treatment agents are necessary. Satraplatin is a third-generation orally-available platinum analog that demonstrated a 33% reduction in the risk of progression in patients ...
Guru, Sonpavde, Cora N, Sternberg
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Leading causes of castration-resistant prostate cancer
Expert Review of Anticancer Therapy, 2015Prostate cancer (PCa) is the second leading cause of cancer-related death in men. Androgen receptor has a key role in the initiation and progression of PCa. Currently, androgen deprivation therapy is the standard treatment for PCa patients due to its effective suppression of androgen receptor signaling.
Mingqian, Lu, Hongda, Lu, Qingzhi, Kong
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Sequential Therapies in Castration-Resistant Prostate Cancer
Future Oncology, 2014153 ISSN 1479-6694 10.2217/FON.13.243 © 2014 Future Medicine Ltd Future Oncol. (2014) 10(2), 153–155 An unprecedented large number of agents capable of prolonging survival is presently available for patients with castrationresistant prostate cancer (CRPC) [1,2].
Carlo, Buonerba, Giuseppe, Di Lorenzo
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Enzalutamide in Castration-Resistant Prostate Cancer
New England Journal of Medicine, 2018Giacomo, Bregni +2 more
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Denosumab in castration-resistant prostate cancer
The Lancet, 2012Athanassios, Kyrgidis +1 more
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Olaparib for Metastatic Castration-Resistant Prostate Cancer
New England Journal of Medicine, 2020Bivas, Biswas +2 more
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