Results 11 to 20 of about 16,591 (206)

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs. [PDF]

Prostate
ABSTRACT Background The dog is the only large mammal, other than humans, that commonly develops spontaneous prostate cancer (PCa) and is, therefore, considered a valuable model for comparative studies. Estrogens are critical for normal prostate development and contribute to prostatic carcinogenesis in men.
Lothion-Roy J, Aeschlimann L, Hiller LA, Rottenberg S, Mongan NP, Rutland CS, Rakha E, Dean A, Rubin MA, de Brot S.   +9 more
europepmc   +2 more sources

Influence of statins in metastatic castration-resistant prostate cancer patients treated with new antiandrogen therapies: a systematic review and meta-analysis

Einstein (São Paulo), 2022
Objective To evaluate whether the addition of statins to the new antiandrogens (enzalutamide or abiraterone) affects overall survival in patients with metastatic castration-resistant prostate cancer.
Renato Mariano Jr, Kevin Lima Tavares, Renato Panhoca, Marcus Sadi   +3 more
doaj   +1 more source

Impact of clinical trial participation on survival in patients with castration-resistant prostate cancer: a multi-center analysis

BMC Cancer, 2018
Background Clinical trial (CT) participation may confer access to new, potentially active agents before their general availability. This study aimed to investigate the potential survival benefit of participation in investigational CTs of novel hormonal ...
Kyo Chul Koo, Jong Soo Lee, Jong Won Kim, Kyung Suk Han, Kwang Suk Lee, Do Kyung Kim, Yoon Soo Ha, Koon Ho Rha, Sung Joon Hong, Byung Ha Chung   +9 more
doaj   +1 more source

Clinical implications of genomic evaluations for prostate cancer risk stratification, screening, and treatment: a narrative review

Prostate International, 2020
New classification systems based on molecular features have been introduced to improve precision medicine for prostate cancer (PCa). This review covers the increasing risk of PCa and the differences in response to targeted therapy that are related to ...
Jae-Seung Chung, Todd M. Morgan, Sung Kyu Hong   +2 more
doaj   +1 more source

A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

BMC Urology, 2023
Background The significance of metastasis-directed therapy for oligometastatic prostate cancer has been widely discussed, and targeted therapy for progressive sites is a feasible option as a multidisciplinary treatment for castration-resistant prostate ...
Soichiro Yoshida, Taro Takahara, Yuki Arita, Masaya Ito, Sara Hayakawa, Tomohiko Oguchi, Yoshinobu Komai, Noboru Numao, Takeshi Yuasa, Masaharu Inoue, Hiroki Ushijima, Shigehiro Kudo, Yasumasa Shimano, Yuki Nakamura, Yusuke Uchida, Sho Uehara, Hajime Tanaka, Hiroshi Yaegashi, Kouji Izumi, Minato Yokoyama, Yoh Matsuoka, Yasuo Yoshioka, Koji Konishi, Katsuyuki Nakanishi, Akira Nagahara, Akihiro Hirakawa, Ryuji Koike, Fumitaka Koga, Kazuo Nishimura, Atsushi Mizokami, Junji Yonese, Yukio Kageyama, Ryoichi Yoshimura, Yasuhisa Fujii   +33 more
doaj   +1 more source

Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]

, 2014
Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle, Munoz, Javier, Wheler, Jennifer J   +2 more
core   +2 more sources

Primary melanoma of the prostate: case report and review of the literature [PDF]

, 2015
Background: Primary melanoma of the prostate has an extremely rare incidence. Only five cases have been reported in the literature and prognosis is poor. The most likely origin of prostatic melanoma is the transitional epithelium of the prostatic urethra.
Bergmann, Frank, Freier, Gerald, Hadaschik, Boris A., Hassel, Jessica C., Hohenfellner, Markus, Huber, Johannes, Kuru, Timur H., Pahernik, Sascha A., Tosev, Georgi   +8 more
core   +3 more sources

Clinicopathological Features, Treatment, and Outcome of Omani Patients with Metastatic Prostate Cancer

Oman Medical Journal, 2022
Objectives: Prostate cancer (PCa) is the third most common cancer worldwide, with its incidence rising in the Middle East. There is a paucity of data about the clinicopathological features and outcomes of metastatic prostate cancer (mPCa) from the Middle
Shiyam Kumar, Ikram A. Burney, Joseph Kunju, Mohammed Salim Al-Marhoon, Khurrum Mutahir Siddiqui   +4 more
doaj   +1 more source

Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer. [PDF]

, 2016
Adenocarcinomas of the prostate arise as multifocal heterogeneous lesions as the likely result of genetic and epigenetic alterations and deranged cell-cell communication.
Calpini, V., Chiorino, G., Dotto, G.P., Farsetti, A., Lefort, K., Mello-Grand, M., Ostano, P., Scatolini, M.   +7 more
core   +1 more source

Nonmetastatic castration‐resistant prostate cancer treated with salvage focal brachytherapy after external beam radiotherapy

IJU Case Reports, 2021
Introduction The efficacy of salvage local therapy after external beam radiotherapy has recently gained attention. However, a challenge with these therapies is the risk of significant genitourinary and gastrointestinal toxicity.
Soichiro Yoshida, Yoh Matsuoka, Kazuma Toda, Sho Uehara, Hajime Tanaka, Minato Yokoyama, Kazutaka Saito, Ryoichi Yoshimura, Yasuhisa Fujii   +8 more
doaj   +1 more source