Results 51 to 60 of about 16,591 (206)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients [PDF]

, 2016
Background. Neuroendocrine markers, which could indicate for aggressive variants of prostate cancer and Ki67 (a well-known marker in oncology for defining tumor proliferation), have already been associated with clinical outcome in prostate cancer.
Aversa, Cinzia, Barbazza, Renzo, Bonin, Serena, Marongiu, Barbara, Pascale, Mariarosa, Roggero, Enrico, Siracusano, Salvatore, Stanta, Giorgio, Stoffel, Flavio, Sulfaro, Sando   +9 more
core   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Metastatic castration-resistant prostate cancer (mCRPC) treated with 225Ac-PSMA-617. Case report

Brazilian Journal of Oncology, 2019
Metastatic castration-resistant prostate cancer (mCRPC) is an extremely severe disease that relentlessly evolves to death. Over the past few years, we have seen significant improvements in the different types of treatments available, which have ...
Rodrigo Bovolin de Medeiros, Marcus Vinicius Grigolon, Tatianny Paula Araújo, Miguel Srougi   +3 more
doaj   +1 more source

Neuroendocrine cells in the normal, hyperplastic and neoplastic prostate [PDF]

, 1995
Neuroendocrine cells can be demonstrated in normal, hyperplastic and neoplastic prostatic tissues. The products secreted by these cells can be used as tissue and/or serum markers but may also have biological effects.
Kwast, Th.H. (Theo) van der, Noordzij, M.A. (Marinus), Schröder, F.H. (Fritz), Steenbrugge, G.J. (Gert Jan) van   +3 more
core   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Current opinion on the role of testosterone in the development of prostate cancer: a dynamic model [PDF]

, 2015
Background: Since the landmark study conducted by Huggins and Hodges in 1941, a failure to distinguish between the role of testosterone in prostate cancer development and progression has led to the prevailing opinion that high levels of testosterone ...
A Darago, A Discacciati, A Feustel, A Feustel, A Haider, A Jemal, A Marczynska, A Morgentaler, A Morgentaler, A Morgentaler, A Morgentaler, A Neschadim, A Netter, A Nimrod, AD Berger, AH Wu, AK Roy, AM Nomura, American Cancer Society, Amy B. Dailey, AS Prasad, AS Prasad, AS Prasad, AV Patel, AW Hsing, AW Roddam, B Ettinger, B Xu, BA Mohr, Brandie D. Taylor, BW Craig, C Andreini, C Carson 3rd, C Chen, C Couillard, C Huggins, C Huggins, C Wang, C Wang, CA Heinlein, CD Mullins, CH Bock, CJ Frederickson, CJ Frederickson, CL Hanchette, D Hofer, DA Svetec, DM Kelly, E Barrett-Connor, E Giovannucci, E Wehr, EA Platz, EH Allott, EL Rhoden, EM John, ES Orwoll, FJ Hayes, FK Habib, G Karimi, GB Martin, GG Schwartz, GG Schwartz, GG Schwartz, GR Schrodt, HA Feldman, HA Guess, HB Carter, HC Heitkamp, HJ Litman, Hui Hu, HW Baker, I Cheng, IG Levy, J Khoo, J Lindzey, JE Fowler Jr, JF Dorgan, JK Parsons, JS Finkelstein, K McDavid, K Nimptsch, KJ Bell, L Ellis, LC Costello, LC Costello, LD Hayes, LJ Gooren, LJ Vatten, LS Marks, M Brys, M Marcelli, ME Taplin, MT Schweizer, N Orsini, NM Wright, P Whelan, PH Gann, R Gilbert, R Hartoma, R Heikkila, R Ramasamy, R Ross, R Sih, RB Franklin, RC Travis, RJ MacInnis, RL Ferrini, RR Hajjar, S Pilz, S Rohrmann, S Young-McCaughan, SA Oliveria, SJ Winters, SM Gapstur, SS Harris, SS Harris, T Goel, T Okamura, TC Chen, TK Jensen, TM Lane, W Maret, WC Buschemeyer 3rd, WJ Kraemer, WR Miller, Xiaohui Xu, Xinguang Chen   +126 more
core   +5 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Salvage Ultrasound-Guided Robot-Assisted Video-Endoscopic Inguinal Lymphadenectomy (RAVEIL) as a Metastasis-Directed Therapy (MDT) in Oligoprogressive Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Case Report and Review of the Literature

Current Oncology
Background: Metastatic castration-resistant prostate cancer (mCRPC) remains challenging due to progression despite androgen deprivation therapy (ADT).
Rafał B. Drobot, Marcin Lipa, Artur A. Antoniewicz   +2 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source