Results 101 to 110 of about 36,967 (163)
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava+9 more
wiley +1 more source
Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen+6 more
wiley +1 more source
Neural electrodes for brain‐computer interface system: From rigid to soft
Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang+7 more
wiley +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah+9 more
wiley +1 more source
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves+3 more
wiley +1 more source
PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid
Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra+3 more
wiley +1 more source
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley +1 more source
Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley +1 more source