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TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair+17 more
wiley +1 more source
The people smugglers’ business model [PDF]
While discussions continue on how best to go about breaking the people smugglers’ business model, those participating in the debate have not publicly articulated the business model to which they refer. This has significant policy implications, given that
Cat Barker
core
PERBAIKAN BODI DAN PENGECATAN ULANG MOBIL TOYOTA HIACE TAHUN 1981 AB 9010 DN SEBELAH KIRI [PDF]
Tujuan dari proyek akhir yang berjudul perbaikan dan pengecatan bodi mobil Toyota Hiace Tahun 1981 sebelah kiri adalah untuk melakukan proses rekondisi bodi dan cat mobil Toyota Hiace sebelah kiri dan mengetahui hasil setelah dilakukan perbaikan dan ...
Dyan, Wahyudi
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Anatomía quirúrgica del hígado
Motivo de preocupación para el cirujano general ha sido abordar traumatismos y patologías hepáticas probablemente debido a la poca familiaridad con su anatomía lo cual crea inseguridad acerca de las estructuras intrahepáticas, especialmente las venas ...
Bolívar E. Villacis+2 more
doaj
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
Crime and law enforcement: a quick guide to key internet links [PDF]
This Quick Guide provides key internet links to websites with information on crime and law enforcement arrangements and ...
Cat Barker
core
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser+11 more
wiley +1 more source
National security: a quick guide to key internet links [PDF]
This Quick Guide provides key internet links to websites with information on national security arrangements and ...
Cat Barker
core
Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane+14 more
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