Results 251 to 260 of about 303,763 (330)

Polyamine Catabolism [PDF]

, 2020
openaire   +1 more source

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Indole-Acetic Acid Impairs Pseudomonas aeruginosa Virulence and Alters Lung Infection in Mice. [PDF]

Microbiologyopen
Igídio CED, Brito CB, Bezerra RO, Oliveira SN, Teixeira CF, Amorim-Santos BM, Andrade ACO, Rios DL, Pedroso SHSP, Santos SGD, Teixeira MM, Souza DDG, Mata CPSMD, Fagundes CT.   +13 more
europepmc   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

NF-κB restrains nutrient-dependent transcription programs through chromatin modulation in Drosophila. [PDF]

Nucleic Acids Res
Kong X, Li C, Karpac J.
europepmc   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O-Glycan Degradation and Pathogenicity in a Potentially Multidrug-Resistant Clostridium tertium Strain. [PDF]

Microbiologyopen
Kim S, Kang JY, Lee JS.
europepmc   +1 more source

Integrated bioconversion of starchy and hemicellulosic fractions of macauba oil presscake into ethanol by nonconventional yeasts

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Co‐fermentation of hexoses and pentoses from plant biomass to ethanol is a strategy to increase ethanol production from lignocellulosic materials and add value to residues from agroindustrial chains. The macauba (Acrocomia aculeata) is an oleaginous palm‐tree species considered to contribute to development in some regions of Brazil.
Filipe Soares de Freitas, Raquel Valinhas e Valinhas, Felipe Ferreira Silva, Paulo Afonso Granjeiro, Marina Quádrio Raposo Branco Rodrigues, Lílian de Araújo Pantoja, Daniel Bonoto Gonçalves, Alexandre Soares dos Santos   +7 more
wiley   +1 more source

The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications. [PDF]

Ann Intensive Care
Mottale R, Dupuis C, Szklarzewska S, Preiser JC.   +3 more
europepmc   +1 more source