Results 161 to 170 of about 185,752 (258)

Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines. [PDF]

Cell Metab
Troha K, Kambhampati S, Insenga A, Metallo CM, Ayres JS.   +4 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Quantitative Proteomics of Nitrosylated Proteins in Melanoma Using the Biotin-Switch Technique Combined With Tandem Mass Tag Labeling. [PDF]

Bio Protoc
Yadav VK, Fang B, Koomen JM, Srivastava J, Premi S.   +4 more
europepmc   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability. [PDF]

Glia
Popek M, Goryca K, Adamska D, Urban-Ciećko J, Hryniewiecka K, Lipiec M, Krawczyk TG, Rafalko K, Ławicka A, Liddelow SA, Szewczyk LM.   +10 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Tramadol induced hypoxia signaling and paraptosis-like cell death in breast cancer cells via HIF-1α and ATF4 dependent pathways. [PDF]

Redox Rep
Wu ZS, Huang SM, Huang YH.
europepmc   +1 more source

Bio‐Based Wax Interfaces for Droplet Energy Harvesting at Fluoropolymer‐Like Output Levels

Advanced Science, EarlyView.
Replacing unsustainable fluorinated polymers in droplet‐based energy harvesters is usually limited by low power outputs, but carefully selected bio‐based polymers are capable of creating fluoropolymer‐like voltage outputs. Abstract Droplet impact and rebound on solid surfaces has emerged as a promising method for energy harvesting, typically ...
Behnam Kamare, Mahla Shahabi, Matteo Carpi de Resmini, Tiago Fernandes, Fabian Meder   +4 more
wiley   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

A longitudinal cross-country dataset on agricultural productivity and welfare in Sub-Saharan Africa. [PDF]

Sci Data
Bentze T, Wollburg P.
europepmc   +1 more source