Results 151 to 160 of about 31,263 (311)

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

The spatial and multi-omic landscape of Down syndrome leukemogenesis: moving beyond cellular heterogeneity. [PDF]

Exp Hematol Oncol
Peroni E, Amato R, Bado M, Favarato M, Rosato A.   +4 more
europepmc   +1 more source

Digitization, Cataloging & Metadata Mailing (February 2014)

, 2014
Table of contents includes: RDA Notes; (Un-)Controlling Undifferentiated Personal Name Headings; "RDA Basics" Webinars for Early 2014; Digital Preservation Resource Highlight; Call for Presenters for MDL 12th Annual Meeting; Note From the EditorMinitex ...
Minitex Digitization, Cataloging & Metadata Education Unit
core  

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Editorial: Phage-based interventions in livestock: from genomics to translational applications. [PDF]

Front Microbiol
Zapata-Mena S, Vinueza-Burgos C, Calero-Cáceres W.   +2 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Exploring the global mosaic of medicinal plant databases: unveiling nature's pharmacopoeia. [PDF]

Nat Prod Bioprospect
Jiang Y, Jia X, Yang Z.
europepmc   +1 more source

Data‐Driven Discovery of Unconventional Antiferromagnets

Advanced Science, EarlyView.
A high‐throughput workflow that combines the physics‐informed pre‐screening, high‐throughput exchange calculations, Luttinger‐Tisza analysis and symmetry classification is established for accurate identification of unconventional antiferromagnets from the broad structural database.
Qirui Cui, Chenxu Liu, Anna Delin, Kaiyou Wang   +3 more
wiley   +1 more source

Digital technologies in ethnobiology and ethnoecology: methodological opportunities, ethical challenges, and participatory implications. [PDF]

J Ethnobiol Ethnomed
da Silva HTLB.
europepmc   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source