Results 211 to 220 of about 174,911 (328)

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

open access: yesAdvanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

open access: yesAdvanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang   +5 more
wiley   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

open access: yesAdvanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee   +6 more
wiley   +1 more source

Spring 1922 [catalog] /

open access: gold, 1922
Clarence B. Fargo   +2 more
openalex   +2 more sources

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