Results 61 to 70 of about 45,570 (302)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Global catalog of soil moisture droughts over the past four decades [PDF]

Hydrology and Earth System Sciences
At the global scale, droughts can be described by many variables, expressing their extent, duration, dynamics, and severity. To identify common features in global land drought events (GLDEs) based on soil moisture, we present a robust method for their ...
J. Řehoř, J. Řehoř, R. Brázdil, R. Brázdil, O. Rakovec, O. Rakovec, M. Hanel, M. Fischer, M. Fischer, R. Kumar, J. Balek, J. Balek, M. Poděbradská, M. Poděbradská, V. Moravec, V. Moravec, L. Samaniego, L. Samaniego, Y. Markonis, M. Trnka, M. Trnka   +20 more
doaj   +1 more source

Special Libraries, December 1975 [PDF]

, 1975
Volume 66, Issue 12https://scholarworks.sjsu.edu/sla_sl_1975/1009/thumbnail ...
Special Libraries Association
core   +1 more source

Data-Mining a Large Digital Sky Survey: From the Challenges to the Scientific Results [PDF]

, 1997
The analysis and an efficient scientific exploration of the Digital Palomar Observatory Sky Survey (DPOSS) represents a major technical challenge. The input data set consists of 3 Terabytes of pixel information, and contains a few billion sources.
de Carvalho, R. R., Djorgovski, S. G., Gal, R. R., Gray, A., Odewahn, S. C., Roden, J., Stolorz, P.   +6 more
core   +3 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Desafios na Construção de uma biblioteca digital [PDF]

, 1999
Analysis of the possible major problems to be faced in several university library sectors during and after the implementation of a digital library project.
Cunha, Murilo
core  

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Using The 300 Physical Desciptions Field and Its Components of The MARC Standard in Manuscripts

Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi, 2016
Manuscript cataloging is a process which requires more collaboration and expertise compared to published works. Determination of artistic; physical and content characteristics of manuscripts and their classification into correct and standard ...
Hakan ANAMERİÇ
doaj  

Application of Deep-learning Methods in the Classification of Chinese Buddhist Canonical Catalogs [PDF]

Journal of Library and Information Studies
This research focuses on the classification of Chinese Buddhist scripture catalogs, employing advanced deep learning methods to develop an automatic classification mechanism.
Shu-Ling Huang, Yu-Chun Wang, Jen-Jou Hung   +2 more
doaj   +1 more source