Results 151 to 160 of about 209,821 (326)

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

open access: yesAdvanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang   +8 more
wiley   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin   +11 more
wiley   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

open access: yesAdvanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan   +16 more
wiley   +1 more source

Subject Cataloging in a Cooperative Cataloging Environment

open access: yes, 2004
The Andrew W. Mellon Foundation and the National Library of Estonia organized a Conference on Union Catalogs which took place in Tallinn, in the National Library of Estonia on October 17–19, 2002. The Conference presented and discussed analytical papers dealing with various aspects of designing and implementing union catalogs and shared cataloging ...
openaire   +2 more sources

Cryo‐Exfoliation Synthesis of Borophene and its Application in Wearable Electronics

open access: yesAdvanced Science, EarlyView.
This article introduces a novel cryo‐exfoliation method for synthesizing borophene, utilizing rapid quenching with liquid nitrogen and mild sonication to achieve scalable, high‐purity nanosheets. The study explores advanced characterizations, molecular dynamics simulations, and borophene‐based nanocomposites for wearable electronics, demonstrating its ...
Zhixuan Li   +6 more
wiley   +1 more source

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