Results 161 to 170 of about 196,002 (296)

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

The Clinical and Translational Science Award compendium of dissemination and implementation science resource catalogs: Capacity building tools for clinical and translational scientists. [PDF]

J Clin Transl Sci
Lennox LA, Shelton RC, Rohweder CL, Kwan BM.   +3 more
europepmc   +1 more source

Earthquake Catalog‐Based Machine Learning Identification of Laboratory Fault States and the Effects of Magnitude of Completeness [PDF]

, 2018
Nicholas Lubbers, David C. Bolton, Jamaludin Mohd-Yusof, Chris Marone, Kipton Barros, Paul A. Johnson   +5 more
openalex   +1 more source

THE CHANDRA DEEP FIELD-SOUTH SURVEY: 7 MS SOURCE CATALOGS

, 2016
B. Luo, W. Brandt, Y. Xue, B. Lehmer, D. Alexander, F. Bauer, F. Vito, G. Yang, A. Basu-Zych, A. Comastri, R. Gilli, Q. Gu, A. Hornschemeier, A. Koekemoer, T. Liu, V. Mainieri, M. Paolillo, P. Ranalli, P. Rosati, D. Schneider, O. Shemmer, I. Smail, M. Sun, P. Tozzi, C. Vignali, J.-X. Wang   +25 more
semanticscholar   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

A Deep-Learning-Based Real-Time Microearthquake Monitoring System (RT-MEMS) for Taiwan. [PDF]

Sensors (Basel)
Sun WF, Pan SY, Liu YH, Kuo-Chen H, Ku CS, Lin CM, Fu CC.   +6 more
europepmc   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Graphic medicine in academic health science library collections. [PDF]

J Med Libr Assoc
Chan J, Berg MH, Bullers K, Lue TY.
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

TRACKing tandem repeats: a customizable pipeline for identification and cross-species comparison. [PDF]

Bioinform Adv
Adam CL, Rocha J, Sudmant P, Rohlfs R.
europepmc   +1 more source