Results 241 to 250 of about 196,002 (296)

RING‐Between‐RING‐Type E3 Ligase Ariadne‐Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein

open access: yesAdvanced Science, EarlyView.
The plant RING‐between‐RING (RBR)‐type E3 ligase, Ariadne‐like protein 8 (ARI8), ubiquitinates and degrades a viral movement protein, restricting virus spread. ARI8 also inhibits other triple gene block 1 (TGB1)‐containing viruses, revealing a broad‐spectrum antiviral role.
Wenli Li   +12 more
wiley   +1 more source

Satterthwaite's seed catalog : 1926 /

open access: gold, 1926
Satterthwaite Seed Store.   +1 more
openalex   +2 more sources

Soil Nutrient Enrichment Induces Trade‐Offs in Bacterial Life‐History Strategies Promoting Plant Productivity

open access: yesAdvanced Science, EarlyView.
Soil nutrient enrichment induces the trade‐offs between bacterial functional potential and growth‐rate potential. Such trade‐offs favor specific plant‐beneficial species and genes, playing a pivotal role in determining plant productivity. These findings enhance the understanding of the microbial responses in agroecosystems to ongoing global ...
Yuanyuan Yan   +5 more
wiley   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

open access: yesAdvanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie   +22 more
wiley   +1 more source

Enzalutamide‐Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone‐Sensitive Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang   +14 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He   +17 more
wiley   +1 more source

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