This study elucidates a molecular mechanism enabling species coexistence between parasitoid wasps, showing how Asobara japonica uses a set of novel venom proteins to delay host development and exploit older hosts, thereby achieving temporal niche partitioning with Leptopilina drosophilae. Abstract Interspecific competition can drive species coexistence
Junwei Zhang +11 more
wiley +1 more source
NCRAD: Advancing Alzheimer's research through high-quality biospecimens and data. [PDF]
Edler MC +4 more
europepmc +1 more source
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu +11 more
wiley +1 more source
Dike volume derived from seismicity as a gauge of fracture toughness and propagation dynamics. [PDF]
Konstantinou KI.
europepmc +1 more source
NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du +14 more
wiley +1 more source
Traditional Chinese medicine-based therapeutics for Pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome. [PDF]
Pan Y, Gangwar S, Abbas M, Raza K.
europepmc +1 more source
MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang +18 more
wiley +1 more source
A comprehensive reference catalog of human skin DNA virome reveals novel viral diversity and microenvironmental influences. [PDF]
Li Z +13 more
europepmc +1 more source
Trends in the availability and prices of quality-assured tuberculosis drugs: a systematic analysis of Global Drug Facility Product Catalogs from 2001 to 2024. [PDF]
Kohler S +4 more
europepmc +1 more source

