Results 231 to 240 of about 1,051,140 (334)
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang+10 more
wiley +1 more source
Iron‐based nanocomposites are widely used for trace heavy metal removal, but the low utilization of HFO nanoparticles remains a challenge. Here, a metal‐phenolic network (MPN) strategy is proposed to confine nano‐HFO within polystyrene beads, creating a negative electrostatic field and optimizing electron density at oxygen sites. This approach enhances
Manyu Zhang+9 more
wiley +1 more source
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai+9 more
wiley +1 more source
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang+6 more
wiley +1 more source