Results 281 to 290 of about 1,137,990 (347)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Rapidly and reproducibly building a comprehensive catalogue of resistance-associated variants for M. tuberculosis

Adlard D, Malone KM, Westhead J, Hunt M, Thai H, Colpus M, Turner RD, Omar SV, Eyre DW, Ismail N, Walker TM, Peto TE, Crook DW, Iqbal Z, Fowler PW.   +14 more
europepmc   +1 more source

Inhibition of <i>PKCθ</i> Abrogates CD8⁺ T Cell-Mediated Neurotoxicity in Murine Cerebral Malaria. [PDF]

Biomedicines
Albrecht-Schgör K, Stefan VE, Steinlechner M, Humer D, Siegmund K, Peer S, Gruber T, Überegger M, Zur Nedden S, Baier-Bitterlich G, Lackner P, Schmutzhard E, Thuille N, Klepsch V, Baier G.   +14 more
europepmc   +1 more source

[Catalogue] /

, 1905
openaire   +2 more sources

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Quantifying coding integrity and reliability of ICD-11 MMS for rare disease registration: a case study of the Chinese rare disease catalogue. [PDF]

BMC Med Inform Decis Mak
Bai X, Guo J, Zhang M, Wang Y, Li N.
europepmc   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Cohort Profile: Swiss Personalized Health Network Cohort Consortium

Bochud M, Tiali SEB, Armida J, Wissa R, Österle S, Blanco JM, Ghobril JP, Henchoz Y, Pittet V, Benkert P, Kuhle J, Castelao E, Preisig M, Chizzolini C, Günthard HF, Kusejko K, Imboden M, Probst-Hensch N, Koller M, Marques-Vidal P, Vollenweider P, Pruijm M, Rauch A, Ribi C, Scherer A, Tellenbach C, Ponte B, Vaucher J, Fortier I.   +28 more
europepmc   +1 more source

Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns. [PDF]

Cell Mol Life Sci
Wróblewska-Schmude A, Audzeyenka I, Mallek W, Wysocka M, Lesner A, Narajczyk M, Gajdowska F, Gutowska-Owsiak D, Kulesza T, Rogacka D, Piwkowska A.   +10 more
europepmc   +1 more source

Catalogue /

, 1902
openaire   +2 more sources